Aldosterone plays an important role in the regulation of electrolyte and water homeostasis
and in blood pressure maintenance. The latest studies have revealed involvement of this …

The association of CYP11B2 gene polymorphisms with the risk of primary aldosteronism
(PA) was controversial in previous studies. Here we selected two commonly studied …

The aldosterone synthase gene (CYP11B2) is an important candidate gene region in
essential hypertension. We therefore studied the association of-344T/C polymorphism of the …

Anomalies in either of the tightly linked genes encoding the enzymes CYP11B1 (11β-
hydroxylase) or CYP11B2 (aldosterone synthase) can lead to important changes in arterial …

In this study the known promoter region of P450aldo gene (CYP11B2) was investigated in
patients with idiopathic hyperaldosteronism, a disease characterised by hypertension due to …

Objective We previously described an association between the− 344C/T 5′‐untranslated
region (UTR) polymorphism in the CYP11B2 (aldosterone synthase) gene and hypertension …

Objective To explore the relationship between genetic polymorphisms of C-344T in the
promoter region and K173R in the exon 3 of aldosterone synthase gene (CYP11B2) and the …

A thymidine-to-cytosine substitution in the–344 promoter region of the aldosterone synthase
gene (CYP11B2) has been associated with essential hypertension in some but not all …

Genetic polymorphisms of the aldosterone synthase gene (CYP11B2) have been major
targets of studies into the genetic factors involved in hypertension. We have identified three …

Aldosterone synthase is a key enzyme in aldosterone production. Polymorphisms of the
aldosterone synthase gene, CYP11B2, have been suggested to be involved in the …