Background Aldosterone controls sodium balance and intravascular volume, and thus helps
regulate blood pressure. Secretion of aldosterone is mainly regulated at the level of …

Background Aldosterone can affect both blood pressure (BP) and glucose metabolism. We
assessed the association of two polymorphisms− 344 T> C and the 3097 G> A in the …

Gene-association studies of heart size and the aldosterone synthase (CYP11B2) gene have
produced inconsistent results, possibly because of limitations in the sample size and/or the …

Stroke is a complex disease caused by combination of multiple risk factors. Recent findings
have suggested that stroke has a significant genetic component. Various types of genetic …

Aim: We performed a systematic review of the literature by means of a meta-analysis to
evaluate the influence of the aldosterone synthase gene (CYP11B2) C-344T polymorphism …

Context: Variation in the region of chromosome 8 including the genes steroid 11β-
hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) influences mineralocorticoid …

The objective of this study was to examine the extent to which aldosterone synthase
genotype (CYP11B2) and genetic ancestry correlate with atrial fibrillation (AF) and serum …

The distribution of blood pressure in populations is almost certainly dependent on a mosaic
of many genetic loci each with a minute contribution and is under the influence of multiple …

Objective Cytochrome P450 (CYP) 2C9 gene polymorphisms have been implicated in
regulation of the renin–angiotensin–aldosterone system (RAAS) and salt sensitivity in …

Objective: In mice, a lack of cryptochrome results in up-regulation of aldosterone production
due to high expression of the 3β-hydroxysteroid dehydrogenases (HSD3β) gene. The …