Bacterial DNA contains immunostimulatory CpG motifs that interact with toll-like receptor 9
on immune cells to stimulate the production of cytokines, chemokines and immunoglobulins …

Immunostimulatory DNA containing unmethylated CpG motifs is recognized by Toll-like
receptor 9, resulting in the activation of innate immune responses that subsequently amplify …

Oligodeoxynucleotides (ODNs) containing a CpG or certain synthetic dinucleotides, referred
to as immune-stimulatory dinucleotides, induce Toll-like receptor 9 (TLR9)-mediated …

Preclinical and early clinical trials indicate synthetic oligodeoxynucleotides containing
unmethylated CG dinucleotides (CpG ODN) have potent immunostimulatory effects and can …

Synthetic CpG-oligodeoxynucleotides (CpG-ODN) are potent adjuvants that accelerate and
boost antigen-specific immune responses. Toll-like receptor 9 (TLR9) is the cellular receptor …

Signal transduction initiated by TLR such as TLR9, a natural receptor for unmethylated
cytosine‐guanine‐rich motifs (CpG), results in activation of transcription factors, including NF …

Stimulation of toll-like receptor (TLR) 9 activates human plasmacytoid dendritic cells and B
cells, and induces potent innate immune responses in preclinical tumor models and in …

Novel anticancer vaccination regimens that can elicit large numbers of Ag-specific T cells
are needed. When we administered therapeutic vaccines containing the MHC class I …

Tumor immunotherapy has advanced over the past century from the use of crude bacterial
extracts such as Coley's toxins to the use of recombinant cytokines and now to the use of …

Preclinical and early clinical trials indicate synthetic oligodeoxynucleotides containing
unmethylated CG dinucleotides (CpG ODN) have potent immunostimulatory effects. CpG …