In the present study, we aimed to investigate the antibacterial activity and mechanisms of
plectasin-derived peptide NZ2114 in vitro and its therapeutic effects in vivo on broilers …

Plectasin, the first fungus-derived defensin from Pseudoplectania nigrella, is considered to
be one of the most likely substitutes for antibiotics used to cure Staphyloccocus and …

Protegrin (PG) belongs to the antimicrobial peptide cathelicidin family. To date, five protegrin
sequences have been identified in pigs, PG-1 to PG-5. Of these, PG-1 exhibits potent …

Plectasin, the first defensin extracted from a fungus (the saprophytic ascomycete
Pseudoplectania nigrella), is attractive as a prospective antimicrobial agent. The purpose of …

NZ2114 and MP1102 are novel plectasin-derived peptides with potent activity against Gram-
positive bacteria. The antibacterial characteristics and mechanism of NZ2114 and MP1102 …

Abstract Porcine beta defensin 2 (pBD2) is a cationic antimicrobial peptide with broad
spectrum antibacterial activity, which makes it a potential alternative to antibiotics to prevent …

NZ2114, a new variant of plectasin, was overexpressed in Pichia pastoris X-33 via pPICZαA
for the first time. The total secreted protein of fermentation supernatant reached 2,390 mg/l …

Background β-defensins have attracted considerable research interest because of their
roles in protecting hosts from various pathogens. This study was conducted to investigate …

Staphylococcus hyicus (S. hyicus), as the main pathogen of exudative epidermitis (EE) in
piglet, can cause a wide variety of diseases, ranging from bovine mastitis, chicken arthritis …

Plectasin is the first known fungal defensin with potent activity against Gram-positive
bacteria. To evaluate the potential therapeutic application of plectasin, we produced …