Neuroinflammatory response in spinal dorsal horn has been demonstrated to be a critical
factor in oxaliplatin-induced pain. Melatonin has been shown to have anti-inflammatory and …

Aims Oxaliplatin is a key drug in the treatment of colorectal cancer, but it causes acute and
chronic peripheral neuropathies. We previously reported that repeated administration of …

Chemotherapy‐induced neuropathic pain is a debilitating and common side effect of cancer
treatment. Mitochondrial dysfunction associated with oxidative stress in peripheral nerves …

Background Oxaliplatin is an anticancer drug used for the treatment of advanced colorectal
cancer, but it can also cause painful peripheral neuropathies. The pathophysiology of these …

Bone cancer pain (BCP), which seriously affects the quality of life of patients, remains a
clinically challenging problem. Hence, there is an urgent need to investigate new …

Background Neuropathic pain is observed in patients as chemotherapeutic oxaliplatin is
used to treat metastatic digestive tumors; however, the mechanisms responsible for …

Oxaliplatin is commonly used anti-cancer drugs, but it frequently causes peripheral
neuropathic pain. Recently, we reported that elcatonin, a synthetic analog of eel calcitonin …

Oxaliplatin, an organoplatinum compound, is used in the treatment of colorectal cancer, but
its clinical use can be limited due to the development of peripheral neuropathy. Whilst …

Melatonin is a pleiotropic hormone synthesized and secreted mainly by the pineal gland in
vertebrates. Melatonin is an endogenous regulator of circadian and seasonal rhythms …

Oxaliplatin is a chemotherapeutic agent widely used against colorectal and breast cancers;
however, it can also induce peripheral neuropathy that can rapidly occur even after a single …