Is hemoglobin good for cerebral oxygenation and clinical outcome in acute brain injury?

SW English, L McIntyre - Current Opinion in Critical Care, 2018 - journals.lww.com
Hemoglobin is important for cerebral oxygenation and strategies to minimize anemia should
be undertaken. Although higher hemoglobin levels are associated with less cerebral …

Brain tissue oxygenation guided therapy and outcome in non-traumatic subarachnoid hemorrhage

E Gouvea Bogossian, D Diaferia… - Scientific reports, 2021 - nature.com
Brain hypoxia can occur after non-traumatic subarachnoid hemorrhage (SAH), even when
levels of intracranial pressure (ICP) remain normal. Brain tissue oxygenation (PbtO2) can be …

Cerebral oxygen transport failure?: decreasing hemoglobin and hematocrit levels after ischemic stroke predict poor outcome and mortality: STroke: RelevAnt Impact of …

L Kellert, E Martin, M Sykora, H Bauer, P Gussmann… - Stroke, 2011 - Am Heart Assoc
Background and Purpose—Although conceivably relevant for penumbra oxygenation, the
optimal levels of hemoglobin (Hb) and hematocrit (Hct) in patients with acute ischemic stroke …

Admission hemoglobin levels are associated with functional outcome in spontaneous intracerebral hemorrhage

JN Acosta, AC Leasure, LR Kuohn, CP Both… - Critical care …, 2021 - journals.lww.com
OBJECTIVES: To test the hypothesis that admission hemoglobin levels are associated with
outcome in primary, nontraumatic intracerebral hemorrhage. DESIGN: Individual patient …

Diaspirin Crosslinked Hemoglobin (DCLHb TM): Effect of Hemodilution During Focal Cerebral Ischemia in Rats

DJ Cole, RM Schell, JC Drummond - Artificial Cells, Blood …, 1994 - Taylor & Francis
The efficacy of hemodilution therapy, to ameliorate cerebral ischemia, is limited by an
accompanying decrease in oxygen content. We assessed the effect of hemodilution, with …

The HeMoVal study protocol: a prospective international multicenter cohort study to validate cerebrospinal fluid hemoglobin as a monitoring biomarker for aneurysmal …

K Akeret, RM Buzzi, M Saxenhofer, K Bieri, D Chiavi… - BMC neurology, 2022 - Springer
Introduction Preclinical studies provided a strong rationale for a pathophysiological link
between cell-free hemoglobin in the cerebrospinal fluid (CSF-Hb) and secondary brain …

Impact of glycosylated hemoglobin on early neurological deterioration in acute mild ischemic stroke patients treated with intravenous thrombolysis

L Han, Z Hou, M Ma, D Ding, D Wang… - Frontiers in aging …, 2023 - frontiersin.org
Objective In patients with acute mild ischemic stroke treated with intravenous thrombolysis,
the relationship between chronic hyperglycemic status and their early neurological …

Progressive hemorrhagic injury and ischemia after severe traumatic brain injury according to hemoglobin transfusion thresholds: a post-hoc analysis of the transfusion …

ALN Gobatto, D Solla, S Brasil, FS Taccone… - Critical Care, 2024 - Springer
Following severe traumatic brain injury (TBI), up to 50% of patients develop significant
anemia, which compromises oxygen delivery to the cerebral tissue [1]. Furthermore, about …

Combined neuroprotection and reperfusion therapy for stroke: effect of lubeluzole and diaspirin cross-linked hemoglobin in experimental focal ischemia

J Aronowski, R Strong, JC Grotta - Stroke, 1996 - Am Heart Assoc
Background and Purpose In search of a better treatment for acute ischemic stroke, we
evaluated the use of lubeluzole and hemodilution with diaspirin cross-linked hemoglobin …

Use of hemoglobin-based oxygen-carrying solution–201 to improve resuscitation parameters and prevent secondary brain injury in a swine model of traumatic brain …

G Rosenthal, D Morabito, M Cohen… - Journal of …, 2008 - thejns.org
Object Traumatic brain injury (TBI) often occurs as part of a multisystem trauma that may
lead to hemorrhagic shock. Effective resuscitation and restoration of oxygen delivery to the …