Retinal neovascularization (RNV) is a characteristic pathological finding of retinopathy of
prematurity (ROP). Cysteine-rich 61 [Cyr61, also known as CCN family member 1 (CCN1)] …

Background CCN1 (also called Cyr 61) is an extracellular matrix signaling molecule that has
been implicated in neovascularization through its interactions with several endothelial …

Retinal vascular damages are the cardinal hallmarks of retinopathy of prematurity (ROP), a
leading cause of vision impairment and blindness in childhood. Both angiogenesis and …

AIM To investigate the role of CCR7/p-ERK1/2/VEGF signaling in the mouse model of
oxygen-induced retinopathy (OIR). METHODS Neonatal C57BL/6J mice were evenly …

Hypoxia is the most important factor in the pathogenesis of diabetic retinopathy. Cysteine-
rich 61 (Cyr61) is one of the angiogenic factors involved in the development of proliferative …

Purpose The incidence of retinopathy of prematurity (ROP) has increased continuously in
recent years. However, the therapeutic effects of current treatments still remain undesired …

Purpose: Retinal vascular disease represents a major cause for vision loss in the Western
world. Recent research has shown that neuronal and vascular damage are closely related in …

Objective: Retinal neovascularization is a severe complication of many ocular diseases. To
clarify the possible functions and therapeutic potential of long non-coding RNAs (lncRNAs) …

Pathological retinal neovascularization is the most common cause of vision loss. PKCθ has
been shown to play a role in type 2 diabetes, which is linked to retinal neovascularization …

purpose. Cysteine-rich 61 (Cyr61/CCN1) is reported to mediate angiogenesis. In this study,
its role in ocular angiogenesis and proliferative diabetic retinopathy (PDR) was investigated …