Deubiquitinase ubiquitin‐specific protease 9X regulates the stability and function of E3 ubiquitin ligase ring finger protein 115 in breast cancer cells
Q Lu, D Lu, ZM Shao, DQ Li - Cancer science, 2019 - Wiley Online Library
The E3 ubiquitin ligase ring finger protein 115 (RNF 115) is overexpressed in more than half
of human breast tumors and is implicated in the pathogenesis and progression of breast …
of human breast tumors and is implicated in the pathogenesis and progression of breast …
[HTML][HTML] Aberrant USP11 expression regulates NF90 to promote proliferation and metastasis in hepatocellular carcinoma
C Zhang, C Xie, X Wang, Y Huang, S Gao… - American journal of …, 2020 - ncbi.nlm.nih.gov
Growing evidence indicates that deubiquitinase ubiquitin-specific protease 11 (USP11)
plays an important role in cellular function by regulating the stability of its substrates. USP11 …
plays an important role in cellular function by regulating the stability of its substrates. USP11 …
Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis
Abstract Hyperactivation of EGFR/PI3K/AKT is a prominent feature of various human
cancers. Thus, understanding how this molecular cascade is balanced is of great …
cancers. Thus, understanding how this molecular cascade is balanced is of great …
[HTML][HTML] USP17 suppresses tumorigenesis and tumor growth through deubiquitinating AEP
Abstract Ubiquitin-specific protease 17 (USP17), a novel member of deubiquitinase, is
reported to play essential roles in several solid tumors. However, the expression and …
reported to play essential roles in several solid tumors. However, the expression and …
Downregulation of ubiquitin-specific protease 14 (USP14) inhibits breast cancer cell proliferation and metastasis, but promotes apoptosis
L Zhu, S Yang, S He, F Qiang, J Cai, R Liu… - Journal of molecular …, 2016 - Springer
Breast cancer is the second leading cause of cancer-related death in women. Previously,
evidence suggested that ubiquitin-specific protease 14 (USP14) was associated with …
evidence suggested that ubiquitin-specific protease 14 (USP14) was associated with …
USP7 deubiquitinase promotes ubiquitin-dependent DNA damage signaling by stabilizing RNF168
During DNA damage response (DDR), histone ubiquitination by RNF168 is a critical event,
which orchestrates the recruitment of downstream DDR factors, eg BRCA1 and 53BP1 …
which orchestrates the recruitment of downstream DDR factors, eg BRCA1 and 53BP1 …
E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation
X Zhi, D Zhao, Z Wang, Z Zhou, C Wang, W Chen… - Cancer research, 2013 - AACR
To identify novel oncogenic E3 ubiquitin ligases as anticancer targets, we screened an E3
ubiquitin ligase siRNA library containing siRNA pools against 555 individual E3s using the …
ubiquitin ligase siRNA library containing siRNA pools against 555 individual E3s using the …
RNF144A functions as a tumor suppressor in breast cancer through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2
YL Yang, Y Zhang, DD Li, FL Zhang, HY Liu… - Cell Death & …, 2020 - nature.com
Deregulation of E3 ubiquitin ligases is intimately implicated in breast cancer pathogenesis
and progression, but the underlying mechanisms still remain elusive. Here we report that …
and progression, but the underlying mechanisms still remain elusive. Here we report that …
USP31 acetylation at Lys1264 is essential for its activity and cervical cancer cell growth
Y Hou, Y Fan, X Xia, J Pan, J Hou… - Acta Biochimica et …, 2021 - academic.oup.com
Abstract Ubiquitin-specific protease 31 (USP31) is a member of deubiquitinase family that is
involved in nuclear factor-κB activation and sarcomagenesis. However, little is known about …
involved in nuclear factor-κB activation and sarcomagenesis. However, little is known about …
USP28 deficiency promotes breast and liver carcinogenesis as well as tumor angiogenesis in a HIF-independent manner
K Richter, T Paakkola, D Mennerich, K Kubaichuk… - Molecular Cancer …, 2018 - AACR
Recent studies suggest that the ubiquitin-specific protease USP28 plays an important role in
cellular repair and tissue remodeling, which implies that it has a direct role in …
cellular repair and tissue remodeling, which implies that it has a direct role in …