SARS-CoV-2 BA. 1 variant is neutralized by vaccine booster–elicited serum but evades most convalescent serum and therapeutic antibodies

S Lusvarghi, SD Pollett, SN Neerukonda… - Science Translational …, 2022 - science.org
The rapid spread of the highly contagious Omicron variant of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) along with its high number of mutations in the spike …

[HTML][HTML] Antibody titers and breakthrough infections with Omicron SARS-CoV-2

C Dimeglio, M Migueres, JM Mansuy… - The Journal of …, 2022 - ncbi.nlm.nih.gov
Recent studies indicated that the strong immune evasion potential of the most recent SARS-
CoV-2 variant, Omicron, results in more frequent reinfections and breakthrough infections …

The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron

L Zhang, Q Li, Z Liang, T Li, S Liu, Q Cui… - Emerging microbes & …, 2022 - Taylor & Francis
The emergence of Omicron/BA. 1 has brought new challenges to fight against SARS-CoV-2.
A large number of mutations in the Spike protein suggest that its susceptibility to immune …

Reduced sensitivity of commercial spike-specific antibody assays after primary infection with the SARS-CoV-2 Omicron variant

DN Springer, T Perkmann, CM Jani… - Microbiology …, 2022 - Am Soc Microbiol
ABSTRACT The SARS-CoV-2 Omicron variant is characterized by substantial changes in
the antigenic structure of the Spike (S) protein. Therefore, antibodies induced by primary …

Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine–elicited human sera

A Muik, BG Lui, AK Wallisch, M Bacher, J Mühl… - Science, 2022 - science.org
The globally circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variant of concern Omicron (B. 1.1. 529) has a large number of mutations, especially in the …

mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant

WF Garcia-Beltran, KJS Denis, A Hoelzemer, EC Lam… - Cell, 2022 - cell.com
Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.
1/B. 1.1. 529) harboring up to 36 mutations in spike protein, the target of neutralizing …

Reduced neutralization of SARS-CoV-2 Omicron variant by vaccine sera and monoclonal antibodies

A Wilhelm, M Widera, K Grikscheit, T Toptan, B Schenk… - MedRxiv, 2021 - medrxiv.org
Due to numerous mutations in the spike protein, the SARS-CoV-2 variant of concern
Omicron (B. 1.1. 529) raises serious concerns since it may significantly limit the antibody …

Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA. 1 attenuation

DY Chen, CV Chin, D Kenney, AH Tavares, N Khan… - Nature, 2023 - nature.com
Abstract The SARS-CoV-2 Omicron variant is more immune evasive and less virulent than
other major viral variants that have so far been recognized,,,,,,,,,,–. The Omicron spike (S) …

Booster with Ad26. COV2. S or Omicron-adapted vaccine enhanced immunity and efficacy against SARS-CoV-2 Omicron in macaques

L Solforosi, LMM Costes, JTBM Tolboom… - Nature …, 2023 - nature.com
Omicron spike (S) encoding vaccines as boosters, are a potential strategy to improve COVID-
19 vaccine efficacy against Omicron. Here, macaques (mostly females) previously …

Limited neutralisation of the SARS-CoV-2 Omicron subvariants BA. 1 and BA. 2 by convalescent and vaccine serum and monoclonal antibodies

A Wilhelm, M Widera, K Grikscheit, T Toptan… - …, 2022 - thelancet.com
Summary Background In recent months, Omicron variants of SARS-CoV-2 have become
dominant in many regions of the world, and case numbers with Omicron subvariants BA. 1 …