The human genetic code encrypted in thousands of genes holds the secret for synthesis of
proteins that drive all biological processes necessary for normal life and death. Though the …

Gene therapies are currently one of the most investigated therapeutic modalities in both the
preclinical and clinical settings and have shown promise in treating a diverse spectrum of …

Neurological disorders–disorders of the brain, spine and associated nerves–are a leading
contributor to global disease burden with a shockingly large associated economic cost …

Glioblastoma (GBM) is the most common and aggressive primary brain tumor in the adult
population and it carries a dismal prognosis. Inefficient drug delivery across the blood brain …

Cancer has been, from the beginning, a target of intense research for gene therapy
approaches. Currently, more than 60% of all on-going clinical gene therapy trials worldwide …

Throughout its 40-year history, the field of gene therapy has been marked by many
transitions. It has seen great strides in combating human disease, has given hope to patients …

Viral vectors have been used for a broad spectrum of gene therapy for both acute and
chronic diseases. In the context of cancer gene therapy, viral vectors expressing anti-tumor …

Applications of viral vectors have found an encouraging new beginning in gene therapy in
recent years. Significant improvements in vector engineering, delivery, and safety have …

Gene therapy is a technique involving the modification of an individual's genes for treating a
particular disease. The key to effective gene therapy is an efficient carrier delivery system …

▪ Abstract Broadly defined, the concept of gene therapy involves the transfer of genetic
material into a cell, tissue, or whole organ, with the goal of curing a disease or at least …