Drugs are prescribed to manage or prevent symptoms and diseases, but may sometimes
cause 20 unexpected toxicity to muscles. The symptomatology and clinical manifestations of …

What is known and objective: Muscle toxicity is the most significant adverse effect related to
statins. The aim of the study was to analyse the clinical course and achievement of LDL‐C …

Background. Muscular complaints are known side-effects of statin therapy, ranging from
myalgia to clinically important myositis and rhabdomyolysis. We investigated the statin use …

Statin myotoxicity may be prevented in many cases by anticipation of drug–drug interactions.
On the contrary, undue withdrawal of statins owing to minor myalgias should be avoided. A …

Each of the statins may cause myalgia or rhabdomyolysis. Factors which increase the
plasma concentrations of statins are associated with an increase in the risk of myalgia …

Statins are effective drugs to reduce cardiovascular events secondary to dyslipidemia;
however, they cause frequent undesirable side effects. The incidence of statin-induced …

Conclusion As most individuals on statins are 'high-risk'patients, they tend to be on multiple
agents for cardiovascular disease which may interact with their statin. Progression of …

BACKGROUND: The recent withdrawal of cerivastatin by the manufacturer has led to an
interest in hydroxymethylglutaryl-coenzyme A (HMG-CoA) inhibitors and the incidence of …

Statin therapy has a very important role in decreasing cardiovascular risk, and treatment non-
compliance may therefore be a concern in high cardiovascular risk patients. Myotoxicity is a …

The spectrum of statin-induced myopathy includes myalgias and weakness, with or without
CK elevation, and in its most severe form rhabdomyolysis with renal failure. Myalgias are not …