In this work, a scale-up strategy based on the principles of direct design and quality-by-
control (QbC) was applied and investigated using direct nucleation control (DNC). Process …

In this work, a rapid direct design approach for crystallization processes was implemented
using the novel Quality-by-Control (QbC) framework by sequentially applying antisolvent …

Antisolvent crystallization of indomethacin (IMC) was investigated in this work by using an
acetone–methanol (66.5–33.5 wt%) mixture as solvent and water as antisolvent. Selecting …

In this paper, a model-based optimal strategy is presented for the control of particle size in
antisolvent crystallization. Size is controlled on demand by dynamic optimization using a …

The objective of the research was to improve the process design of a combined antisolvent–
cooling crystallization to reduce the degree of agglomeration of a real active pharmaceutical …

Particle size distribution (PSD) is one of the critical attributes of crystals. PSD not only
influences downstream processes but also controls final product performance in …

In-situ attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy and
focused-beam reflectance measurement (FBRM) were used to monitor and control the …

The issues regarding the design and implementation of on‐line optimal control strategies of
crystal properties in nonisothermal antisolvent crystallization processes to control particles' …

Antisolvent crystallization is a crystallization technique, which is normally operated
isothermally. However, non‐isothermal operation is on occasions performed for solutes that …

Innovations in the continuous crystallization field are required for the pharmaceutical
industry to go through the paradigm shift from batch to continuous processing. To do so …