Hepatocyte growth factor twenty years on: Much more than a growth factor

T Nakamura, K Sakai, T Nakamura… - Journal of …, 2011 - Wiley Online Library
Liver regeneration depends on the proliferation of mature hepatocytes. In the 1980s, the
method for the cultivation of mature hepatocytes provided an opportunity for the discovery of …

Hepatocyte growth factor: from diagnosis to clinical applications

H Funakoshi, T Nakamura - Clinica chimica acta, 2003 - Elsevier
Hepatocyte growth factor (HGF), initially identified and molecularly cloned as a potent
mitogen of primary cultured hepatocytes, has multiple activities in a variety of tissues during …

Hepatocyte growth factor: molecular structure and implications for a central role in liver regeneration

K MATSUMOTO, T NAKAMURA - Journal of gastroenterology …, 1991 - Wiley Online Library
Hepatocyte growth factor (HGF) is a most potent factor for mature parenchymal hepatocytes
in primary culture and may act as a trigger for liver regeneration. We purified HGF from rat …

Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions.

K Matsumoto, T Nakamura - Critical reviews in oncogenesis, 1992 - europepmc.org
Hepatocyte growth factor (HGF) is the most potent mitogen for mature hepatocytes and
seems to act as a hepatotropic factor that has not been purified over the past 30 years. HGF …

Roles of HGF as a pleiotropic factor in organ regeneration.

K Matsumoto, T Nakamura - Exs, 1993 - europepmc.org
Hepatocyte growth factor (HGF) has been discovered, purified, and molecularly cloned as a
potent mitogen for mature hepatocytes. HGF is produced by mesenchymal cells and …

Hepatocyte growth factor

GK Michalopoulos, R Zarnegar - Hepatology, 1992 - journals.lww.com
The two papers in this issue of Hepatology (1, 2) dealing with hepatocyte growth factor
(HGF) underscore the increasing importance of this novel growth factor in relation to hepatic …

[PDF][PDF] The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis.

R Zarnegar, GK Michalopoulos - The Journal of cell biology, 1995 - europepmc.org
ESEARCH performed over the past few years, in particular, has made it clear that, in
addition to the liver, hepatocyte growth factor (HGF) 1 affects virtually every tissue in the …

Structure and function of hepatocyte growth factor

T Nakamura - Progress in growth factor research, 1991 - Elsevier
Hepatocyte growth factor (HGF), a potent mitogen for mature hepatocytes in primary culture,
was first found in sera of partial hepatectomized rats and seems to be a hepatotrophic factor …

Emerging multipotent aspects of hepatocyte growth factor

K Matsumoto, T Nakamura - The journal of biochemistry, 1996 - academic.oup.com
Specific tissue interactions between epithelia and mesenchyme (or stroma), eg, epithelial-
mesenchymal (or-stromal) interactions mediate crucial aspects of normal development and …

The discovery of hepatocyte growth factor (HGF) and its significance for cell biology, life sciences and clinical medicine

T Nakamura, S Mizuno - Proceedings of the Japan Academy, Series …, 2010 - jstage.jst.go.jp
It has been more than 25 years since HGF was discovered as a mitogen of hepatocytes.
HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility …