ABSTRACT The lipid molecule phosphatidylinositol (4, 5)-bisphosphate [PI (4, 5) P 2]
controls all aspects of plasma membrane (PM) function in animal cells, from its selective …

Abstract Phosphatidylinositol 4, 5-bisphosphate [PI (4, 5) P 2] is a minor lipid of the inner
leaflet of the plasma membrane that controls the activity of numerous proteins and serves as …

In the almost 70 years since the first hints of its existence, the phosphoinositide,
phosphatidyl-D-myo-inositol 4, 5-bisphosphate has been found to be central in the …

Abstract During recent decades, PI (4) P (phosphoinositol-4-phosphate) has been described
as a key regulator of a wide range of cellular functions such as organelle biogenesis, lipid …

Phosphoinositides are an important class of anionic, low abundance signaling lipids
distributed throughout intracellular membranes. The plasma membrane contains three …

Abstract Phosphatidylinositol 4, 5-bisphosphate (PI4, 5P 2) is an essential lipid messenger
with roles in all eukaryotes and most aspects of human physiology. By controlling the …

Located at the inner leaflet of the plasma membrane (PM), phosphatidyl-inositol 4, 5-
bisphosphate [PI (4, 5) P2] composes only 1–2 mol% of total PM lipids. With its synthesis …

Phosphatidylinositol 4, 5-bisphosphate [PI (4, 5) P 2] is a multi-functional lipid that regulates
several essential subcellular processes in eukaryotic cells. In addition to its well-established …

Phosphatidylinositol phosphate kinases (PIPKs) generate a lipid messenger
phosphatidylinositol 4, 5-bisphosphate (PI4, 5P 2) that controls essentially all aspects of …

Abstract Phosphatidylinositol 4, 5 bisphosphate (PI4, 5P 2) is a critical second messenger
that regulates a myriad of diverse cellular activities including modulation of the actin …