Uremic patients are prone to widespread ectopic extraskeletal calcification resulting from an
imbalance of systemic inorganic phosphate (Pi). There can be serious consequences of this …

Background Serum phosphate is a known risk factor for cardiovascular events and mortality
in people with chronic kidney disease (CKD), however data on the association of these …

Phosphorus is an essential mineral that plays a crucial role in cell structure and metabolism.
In living organisms, phosphorus exists surrounded by four oxygen atoms to form phosphate …

Background Despite epidemiologic evidence for increased cardiovascular morbidity and
mortality associated with both high dietary and serum phosphate in humans with normal …

Vascular calcification or mineralization is a major complication seen in patients with
advanced stages of chronic kidney disease (CKD), and it is associated with markedly …

Vascular calcification contributes to the high risk of cardiovascular mortality in chronic kidney
disease (CKD) patients. Dysregulation of calcium (Ca) and phosphate (P) metabolism is …

Background The kidneys maintain acid-base homeostasis through excretion of acid as
either ammonium or as titratable acids that primarily use phosphate as a buffer. In chronic …

Background Optimal phosphate control is an unmet need in chronic kidney disease (CKD).
High serum phosphate increases calcification burden and is associated with mortality and …

Vascular calcification: A stiff challenge for the nephrologists—Does preventing bone disease
cause arterial disease? There has been an explosion of interest in vascular calcification in …

Medial arterial calcification is accelerated in patients with CKD and strongly associated with
increased arterial rigidity and cardiovascular mortality. Recently, a novel in vitro blood test …