The extreme mutator effect of Escherichia coli mutD5 results from saturation of mismatch repair by excessive DNA replication errors.
RM Schaaper, M Radman - The EMBO journal, 1989 - embopress.org
Escherichia coli mutator mutD5 is the most potent mutator known. The mutD5 mutation
resides in the dnaQ gene encoding the proofreading exonuclease of DNA polymerase III …
resides in the dnaQ gene encoding the proofreading exonuclease of DNA polymerase III …
Escherichia coli mutator mutD5 is defective in the mutHLS pathway of DNA mismatch repair.
RM Schaaper - Genetics, 1989 - academic.oup.com
We have previously reported that the Escherichia coli mutator strain mutD5 was defective in
the correction of bacteriophage M13mp2 heteroduplex DNA containing a TG mismatch …
the correction of bacteriophage M13mp2 heteroduplex DNA containing a TG mismatch …
Mechanisms of mutagenesis in the Escherichia coli mutator mutD5: role of DNA mismatch repair.
RM Schaaper - Proceedings of the National Academy of …, 1988 - National Acad Sciences
To investigate the mechanisms of spontaneous mutation in the Escherichia coli mutD5
mutator strain, 502 mutations generated in this strain in the N-terminal part of the lacI gene …
mutator strain, 502 mutations generated in this strain in the N-terminal part of the lacI gene …
Saturation of mismatch repair in the mutD5 mutator strain of Escherichia coli
V Damagnez, MP Doutriaux, M Radman - Journal of bacteriology, 1989 - Am Soc Microbiol
The mutD (dnaQ) gene of Escherichia coli codes for the proofreading activity of DNA
polymerase III. The very strong mutator phenotype of mutD5 strains seems to indicate that …
polymerase III. The very strong mutator phenotype of mutD5 strains seems to indicate that …
Dominant negative mutator mutations in the mutS gene of Escherichia coli
TH Wu, MG Marinus - Journal of bacteriology, 1994 - Am Soc Microbiol
The MutS protein of Escherichia coli is part of the dam-directed MutHLS mismatch repair
pathway which rectifies replication errors and which prevents recombination between …
pathway which rectifies replication errors and which prevents recombination between …
A · T → C · G transversions and their prevention by the Escherichia coli mutT and mutHLS pathways
RM Schaaper, BI Bond, RG Fowler - Molecular and General Genetics …, 1989 - Springer
Escherichia coli mutT strains are strong mutators yielding only A· T→ C· G transversion
mutations. These are thought to result from uncorrected (or unprevented) A· G mispairings …
mutations. These are thought to result from uncorrected (or unprevented) A· G mispairings …
Separation of mutation avoidance and antirecombination functions in an Escherichia coli mutS mutant
MA Calmann, A Nowosielska… - Nucleic acids …, 2005 - academic.oup.com
DNA mismatch repair in Escherichia coli has been shown to be involved in two distinct
processes: mutation avoidance, which removes potential mutations arising as replication …
processes: mutation avoidance, which removes potential mutations arising as replication …
Specificity of Escherichia coli mutD and mutL mutator strains
TH Wu, CH Clarke, MG Marinus - Gene, 1990 - Elsevier
The products of the mutD and mutL genes of Escherichia coli are involved in proofreading
by DNA polymerase III and DNA adenine MTase (Dam)-dependent mismatch repair …
by DNA polymerase III and DNA adenine MTase (Dam)-dependent mismatch repair …
Dominant Negative Mutator Mutations in the mutL Gene of Escherichia Coli
A Aronshtam, MG Marinus - Nucleic acids research, 1996 - academic.oup.com
The mutL gene product is part of the dam-directed mismatch repair system of Escherichia
coli but has no known enzymatic function. It forms a complex on heteroduplex DNA with the …
coli but has no known enzymatic function. It forms a complex on heteroduplex DNA with the …
Mutation spectrum in Escherichia coli DNA mismatch repair deficient ( mutH ) strain
C Rewinski, MG Marinus - Nucleic acids research, 1987 - academic.oup.com
The Dam-directed post-replicatve mismatch repair system of Escherichia coli removes base
pair mismatches from DNA. The products of the mutH, mutL and mutS genes, among others …
pair mismatches from DNA. The products of the mutH, mutL and mutS genes, among others …