Pulmonary fibrosis is the replacement of healthy tissue by an excessive deposition of
extracellular matrix components leading to an irreversible destruction of the lung …

Pulmonary fibrosis is life-threatening and effective treatment is still lacking. To improve
translation of mouse models to man, we introduced an in vivo µCT protocol to repeatedly …

Lung diseases such as fibrosis, asthma, cystic fibrosis, infection and cancer are life-
threatening conditions that slowly deteriorate quality of life and for which our diagnostic …

Structural remodeling in lung disease is progressive and heterogeneous, making temporally
and spatially explicit information necessary to understand disease initiation and …

Experimental in-vivo animal models are key tools to investigate the pathogenesis of lung
disease and to discover new therapeutics. Histopathological and biochemical investigations …

In spite of many compounds identified as antifibrotic in preclinical studies, pulmonary fibrosis
remains a life-threatening condition for which highly effective treatment is still lacking …

Because it provides information on dynamic disease processes, in vivo micro-CT is
increasingly embraced in lung research. To improve the quantitative monitoring of …

In vivo lung micro-computed tomography (micro-CT) is being increasingly embraced in
pulmonary research because it provides longitudinal information on dynamic disease …

Bleomycin (BLM)-induced lung fibrosis is the best characterized mouse model to investigate
lung disease pathogenesis and drug efficacy. µCT imaging has been recently proposed as a …

Obstructive, interstitial, infectious and malignant lung diseases remain among the most
important health challenges and novel or improved therapeutic strategies are essential for …