Islet vascularization is essential for intact islet function and glucose homeostasis. We have
previously shown that primary cilia directly regulate insulin secretion. However, it remains …

Pancreatic islets regulate glucose homeostasis through coordinated actions of hormone-
secreting cells. What underlies the function of the islet as a unit is the close approximation …

Primary cilia are rod-like sensory organelles that protrude from the surface of most
mammalian cells, including the cells of the islet, and mounting evidence supports important …

Pancreatic islets are micro-organs composed of a mixture of endocrine and non-endocrine
cells, where the former secrete hormones and peptides necessary for metabolic …

Type 2 diabetes mellitus is affecting more than 382 million people worldwide. Although
much progress has been made, a comprehensive understanding of the underlying disease …

Primary cilia are sensory organelles present in many cell types. Based on an array of
microtubules termed axoneme they form a specialized membrane compartment partaking in …

Primary cilia are specialized cell-surface organelles that mediate sensory perception and, in
contrast to motile cilia and flagella, are thought to lack motility function. Here, we show that …

Primary cilia as a signaling organelle have garnered recent attention as a regulator of
pancreatic islet function. These rod-like sensors exist on all major islet endocrine cell types …

Primary cilia are microtubule-based sensory and signaling organelles on the surfaces of
most eukaryotic cells. Despite their early description by microscopy studies, islet cilia had …

Pancreatic islets are highly vascularized mini-organs, and vascular endothelial growth factor
(VEGF)-A is a critical factor in the development of islet vascularization. To investigate the …