Macrophage plasticity, polarization and function in response to curcumin, a diet-derived polyphenol, as an immunomodulatory agent

A Mohammadi, CN Blesso, GE Barreto… - The Journal of nutritional …, 2019 - Elsevier
Monocytes and macrophages are important cells of the innate immune system that have
diverse functions, including defense against invading pathogens, removal of dead cells by …

[HTML][HTML] Curcumin modulates macrophage polarization through the inhibition of the toll-like receptor 4 expression and its signaling pathways

Y Zhou, T Zhang, X Wang, X Wei, Y Chen… - Cellular Physiology and …, 2015 - karger.com
Background: Curcumin, the active ingredient in curcuma rhizomes, has a wide range of
therapeutic effects. However, its atheroprotective activity in human acute monocytic …

Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-κB as potential targets

GY Kim, KH Kim, SH Lee, MS Yoon, HJ Lee… - The Journal of …, 2005 - journals.aai.org
Curcumin has been shown to exhibit anti-inflammatory, antimutagenic, and anticarcinogenic
activities. However, the effect of curcumin on the maturation and immunostimulatory function …

Therapeutic effects of curcumin in inflammatory and immune‐mediated diseases: A nature‐made jack‐of‐all‐trades?

E Abdollahi, AA Momtazi, TP Johnston… - Journal of cellular …, 2018 - Wiley Online Library
Curcumin is a dietary polyphenol from turmeric with numerous pharmacological activities.
Novel animal and human studies indicate that curcumin can affect different immune cells …

Reprogramming M1-to-M2 Phenotype to Alleviate Inflammation: Using Liposomal Curcumin as a Tool to Redefine Macrophage Functionality

S Nasra, T Shah, M Bhatt, R Chaudhari… - ACS Applied Bio …, 2023 - ACS Publications
The versatile nature of macrophages and their ability to switch between various activation
states plays a pivotal role in both promoting and inhibiting inflammatory processes. In …

Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases

M Sadeghi, S Dehnavi, A Asadirad, S Xu… - …, 2023 - Springer
Chemokines belong to the family of cytokines with chemoattractant properties that regulate
chemotaxis and leukocyte migration, as well as the induction of angiogenesis and …

Immunomodulatory and therapeutic activity of curcumin

RM Srivastava, S Singh, SK Dubey, K Misra… - International …, 2011 - Elsevier
Inflammation is a disease of vigorous uncontrolled activated immune responses.
Overwhelming reports have suggested that the modulation of immune responses by …

Curcumin: a modulator of inflammatory signaling pathways in the immune system

KR Kahkhaie, A Mirhosseini, A Aliabadi… - …, 2019 - Springer
Curcumin is a natural compound derived from the spice, turmeric, that has been extensively
reported for its efficacy in controlling or treatment of several inflammatory diseases. There is …

Modulation of neutrophil motility by curcumin: implications for inflammatory bowel disease

CB Larmonier, MT Midura-Kiela… - Inflammatory bowel …, 2011 - academic.oup.com
Background Neutrophils (PMN) are the first cells recruited at the site of inflammation. They
play a key role in the innate immune response by recognizing, ingesting, and eliminating …

Chlorogenic acid potentiates the anti-inflammatory activity of curcumin in LPS-stimulated THP-1 cells

A Bisht, M Dickens, K Rutherfurd-Markwick, R Thota… - Nutrients, 2020 - mdpi.com
The anti-inflammatory effects of curcumin are well documented. However, the bioavailability
of curcumin is a major barrier to its biological efficacy. Low-dose combination of …