Two types of pertussis vaccines are currently available: the first-generation, whole-cell (wP)
and more recent, acellular (aP) vaccines. The aP vaccine has replaced the wP vaccine in …

Duration of vaccine-induced immunity plays a key role in the epidemiology and in the
pattern of transmission of a vaccine-preventable disease. In the case of whooping cough, its …

The significant burden of disease due to pertussis, which predominantly affects newborns
during their first few months of life, was substantially decreased following the introduction of …

Pertussis is a highly communicable acute respiratory infection caused by Bordetella
pertussis. Immunity is not lifelong after natural infection or vaccination. Pertussis outbreaks …

Vaccines against pertussis have been used for more than a hundred years. This review
describes the development of whole-cell (wP) and acellular pertussis (aP) vaccines, which …

Pertussis is a highly contagious respiratory disease caused by Bordetella pertussis.
However, after the introduction of the whole-cell pertussis vaccine (wP), the annual …

Pertussis is a severe respiratory disease that can be fatal in young infants. Its main
aetiological agent is the Gram-negative micro-organism Bordetella pertussis. Vaccines …

Pertussis is an epidemic disease caused by Bordetella pertussis and also to a lesser extent
by Bordetella parapertussis. Classical illness lasts 4–8 weeks and is characterized by …

Pertussis, which is caused by Bordetella pertussis, has plagued humans for at least 800
years, is highly infectious and can be fatal in the unvaccinated, especially very young …

First generation whole-cell (wP) and second generation acellular (aP) pertussis vaccines
have been highly effective in preventing childhood deaths due to pertussis, yet both …