A pivotal metabolic function of insulin is the stimulation of glucose uptake into muscle and
adipose tissues. The discovery of the insulin-responsive glucose transporter type 4 (GLUT4) …

In muscle and fat cells, insulin stimulates the delivery of the glucose transporter GLUT4 from
an intracellular location to the cell surface, where it facilitates the reduction of plasma …

GLUT4 is regulated by its intracellular localization. In the absence of insulin, GLUT4 is
efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon …

GLUT4 is a mammalian facilitative glucose transporter that is highly expressed in adipose
tissue and striated muscle. In response to insulin, GLUT4 moves from intracellular storage …

The effect of insulin to acutely stimulate glucose uptake into muscle and adipose tissue is
essential for normal glucose homeostasis. The GLUT4 glucose transporter is a major …

The transport of glucose into cells and tissues is a highly regulated process, mediated by a
family of facilitative glucose transporters (GLUTs). Insulin-stimulated glucose uptake is …

Insulin, the major hormonal regulator of glucose transport in humans, has served as a
prototypic molecule for understanding cell signaling pathways since its discovery in 1922. It …

I. Introduction G LUCOSE is the primary energy source for the brain under normal
physiological circumstances and is acutely taken up by other mammalian cells for immediate …

The insulin-responsive glucose transporter GLUT4 plays an essential role in glucose
homeostasis. A novel assay was used to study GLUT4 trafficking in 3T3-L1 fibroblasts …

The GLUT4 glucose transporter is predominantly retained inside basal fat and muscle cells,
and it is rapidly recruited to the plasma membrane with insulin stimulation. There is …