Background Evaluation of impaired left ventricular (LV) filling has focused on intrinsic
causes of LV dysfunction; however, pulmonary vascular changes may contribute to reduced …

Background Severe COPD can lead to cor pulmonale and emphysema and is associated
with impaired left ventricular (LV) filling. We evaluated whether emphysema and airflow …

Rationale: Cigarette smoke exposure is a risk factor for many lung diseases, and histologic
studies suggest that tobacco-related vasoconstriction and vessel loss plays a role in the …

Background COPD and heart failure with preserved ejection fraction overlap clinically, and
impaired left ventricular (LV) filling is commonly reported in COPD. The mechanism …

Radiographic abnormalities of the pulmonary vessels, such as vascular pruning, are
common in advanced airways disease, but it is unknown if pulmonary vascular volumes are …

Background Exposure to cigarette smoke has been shown to lead to vascular remodelling.
Computed tomography (CT) imaging measures of vascular pruning have been associated …

Reduced lung diffusing capacity for carbon monoxide (DLCO) at rest and increased
ventilation (⩒ E)-carbon dioxide output (⩒ CO2) during exercise are frequent findings in …

Background—Left ventricular (LV) mass is an important predictor of heart failure and
cardiovascular mortality, yet determinants of LV mass are incompletely understood …

Background—Chronic obstructive pulmonary disease causes significant morbidity and
concomitant pulmonary vascular disease and cardiac dysfunction are associated with poor …

Background Very severe chronic obstructive pulmonary disease causes cor pulmonale with
elevated pulmonary vascular resistance and secondary reductions in left ventricular filling …