Background Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both
injurious and protective functions, which are thought to diverge at the level of its two cell …

Background Tumour necrosis factor (TNF) is upregulated in the alveolar space early in the
course of ventilator-induced lung injury (VILI). Studies in genetically modified mice indicate …

Background Tumor necrosis factor-α (TNF) is strongly implicated in the development of
acute respiratory distress syndrome (ARDS), but its potential as a therapeutic target has …

Tumor necrosis factor alpha (TNFα) is the most widely studied pleiotropic cytokine of the
TNF superfamily. In pathophysiological conditions, generation of TNFα at high levels leads …

TNF plays a crucial role in the pathogenesis of acute lung injury. However, the expression
profile of its two receptors, p55 and p75, on pulmonary endothelium and their influence on …

To determine the roles of the type 1 tumor necrosis factor (TNF) receptor (TNFR1) in lung
inflammation and antibacterial defense, we exposed transgenic mice lacking TNFR1 …

Background Acute lung injury (ALI), characterized by disruption of the lung alveolar-capillary
membrane barrier and resultant pulmonary edema, and associated with a proteinaceous …

The pulmonary host response to infection and inflammation appears, at least in part, to be
compartmentalized from the systemic host response. Tumor necrosis factor-α (TNF-α) has …

Acute lung injury frequently develops following haemorrhage, and is characterized by
increased proinflammatory cytokine levels and massive neutrophil accumulation in the lung …

Tumor Necrosis Factor (TNF) is a pleiotropic cytokine consisting of soluble and
transmembrane forms, with distinct roles in inflammation and immunity. TNF is an important …