Defects in p21-activated kinase (PAK) lead to dendritic spine abnormalities and are
sufficient to cause cognition impairment. The decrease in PAK in the brain of Alzheimer's …

Defects in p21-activated kinase (PAK) are suspected to play a role in cognitive symptoms of
Alzheimer's disease (AD). Dysfunction in PAK leads to cofilin activation, drebrin …

Defects in dendritic spines and synapses contribute to cognitive deficits in mental retardation
syndromes and, potentially, Alzheimer disease. p21-activated kinases (PAKs) regulate actin …

The deficits in Alzheimer disease (AD) stem at least partly from neurotoxic β‐amyloid
peptides generated from the amyloid precursor protein (APP). APP may also be cleaved …

Defects in dendritic spines are common to several forms of cognitive deficits, including
mental retardation and Alzheimer disease. Because mutation of p21-activated kinase (PAK) …

It has been known that the Alzheimer's disease (AD) is related closely with a synaptic failure,
and the p21-activated kinase (PAK) is well documented to play an important role in the …

There is increasing evidence that aggregation of α‐synuclein contributes to the functional
and structural deterioration in the CNS of Parkinson's disease patients and transgenic …

The Akt kinase has been widely assumed for years as a key downstream effector of the PI3K
signaling pathway in promoting neuronal survival. This notion was however challenged by …

Background Although the roles of p21-activated serine/threonine kinase 1 (PAK1) have
been reported in some neurodegenerative diseases, details regarding neurodegeneration …

Apoptotic pathways and DNA synthesis are activated in neurons in the brains of individuals
with Alzheimer disease (AD). However, the signaling mechanisms that mediate these events …