Cannabidiol enhances the antinociceptive effects of morphine and attenuates opioid-induced tolerance in the chronic constriction injury model

CHA Jesus, MV Ferreira, AT Gasparin, ES Rosa… - Behavioural Brain …, 2022 - Elsevier
Neuropathic pain (NP) is a complex health problem that includes sensorial manifestations
such as evoked and ongoing pain. Cannabidiol (CBD) has shown potential in the treatment …

Cannabidiol modulates chronic neuropathic pain aversion behavior by attenuation of neuroinflammation markers and neuronal activity in the corticolimbic circuit in …

GK Silva-Cardoso, W Lazarini-Lopes, EO Primini… - Behavioural Brain …, 2023 - Elsevier
Chronic neuropathic pain (CNP) is a vast world health problem often associated with the
somatosensory domain. This conceptualization is problematic because, unlike most other …

Cannabidiol effectively reverses mechanical and thermal allodynia, hyperalgesia, and anxious behaviors in a neuropathic pain model: Possible role of CB1 and …

GK Silva-Cardoso, W Lazarini-Lopes, JE Hallak… - …, 2021 - Elsevier
The incidence of chronic pain is high in the general population and it is closely related to
anxiety disorders, which promote negative effects on the quality of life. The cannabinoid …

Distinct interactions of cannabidiol and morphine in three nociceptive behavioral models in mice

H Neelakantan, RJ Tallarida… - Behavioural …, 2015 - journals.lww.com
Cannabinoid and opioid agonists can display overlapping behavioral effects and the
combination of these agonists is known to produce enhanced antinociception in several …

Evaluating the antinociceptive efficacy of cannabidiol alone or in combination with morphine using the formalin test in male and female mice

DE Sepulveda, DP Morris… - Cannabis and …, 2022 - liebertpub.com
Introduction: Phytocannabinoids have emerged as a potential alternative treatment option
for individuals experiencing persistent pain. However, evidence-based research regarding …

[HTML][HTML] Cannabidiol is a potential therapeutic for the affective-motivational dimension of incision pain in rats

K Genaro, D Fabris, ALF Arantes, AW Zuardi… - Frontiers in …, 2017 - frontiersin.org
Background: Pain involves different brain regions and is critically determined by emotional
processing. Among other areas, the rostral anterior cingulate cortex (rACC) is implicated in …

Differential effects of cannabidiol and a novel cannabidiol analog on oxycodone place preference and analgesia in mice: An opioid abuse deterrent with analgesic …

HM Harris, W Gul, MA ElSohly… - Cannabis and …, 2022 - liebertpub.com
Background and Purpose: This study sought to determine whether cannabidiol (CBD) or a
CBD derivative, CBD monovalinate monohemisuccinate (CBD-val-HS), could attenuate the …

Opioid and cannabinoid synergy in a mouse neuropathic pain model

NP Kazantzis, SL Casey, PW Seow… - British Journal of …, 2016 - Wiley Online Library
Background and Purpose Clinical studies have reported that pan‐cannabinoid receptor
agonists may have efficacy in neuropathic pain states and that this might be enhanced by co …

[HTML][HTML] Analgesic effects and impairment in locomotor activity induced by cannabinoid/opioid combinations in rat models of chronic pain

M Alsalem, A Altarifi, M Haddad, B Azab, H Kalbouneh… - Brain sciences, 2020 - mdpi.com
Both opioids and cannabinoids have well-known antinociceptive effects in different animal
models of chronic pain. However, unwanted side effects limit their use. The aim of this study …

Cannabis constituent synergy in a mouse neuropathic pain model

SL Casey, N Atwal, CW Vaughan - Pain, 2017 - journals.lww.com
Cannabis and its psychoactive constituent D9-tetrahydrocannabinol (THC) have efficacy
against neuropathic pain, however, this is hampered by their side effects. It has been …