Cannabidiol enhances the antinociceptive effects of morphine and attenuates opioid-induced tolerance in the chronic constriction injury model
CHA Jesus, MV Ferreira, AT Gasparin, ES Rosa… - Behavioural Brain …, 2022 - Elsevier
Neuropathic pain (NP) is a complex health problem that includes sensorial manifestations
such as evoked and ongoing pain. Cannabidiol (CBD) has shown potential in the treatment …
such as evoked and ongoing pain. Cannabidiol (CBD) has shown potential in the treatment …
Cannabidiol modulates chronic neuropathic pain aversion behavior by attenuation of neuroinflammation markers and neuronal activity in the corticolimbic circuit in …
GK Silva-Cardoso, W Lazarini-Lopes, EO Primini… - Behavioural Brain …, 2023 - Elsevier
Chronic neuropathic pain (CNP) is a vast world health problem often associated with the
somatosensory domain. This conceptualization is problematic because, unlike most other …
somatosensory domain. This conceptualization is problematic because, unlike most other …
Cannabidiol effectively reverses mechanical and thermal allodynia, hyperalgesia, and anxious behaviors in a neuropathic pain model: Possible role of CB1 and …
The incidence of chronic pain is high in the general population and it is closely related to
anxiety disorders, which promote negative effects on the quality of life. The cannabinoid …
anxiety disorders, which promote negative effects on the quality of life. The cannabinoid …
Distinct interactions of cannabidiol and morphine in three nociceptive behavioral models in mice
H Neelakantan, RJ Tallarida… - Behavioural …, 2015 - journals.lww.com
Cannabinoid and opioid agonists can display overlapping behavioral effects and the
combination of these agonists is known to produce enhanced antinociception in several …
combination of these agonists is known to produce enhanced antinociception in several …
Evaluating the antinociceptive efficacy of cannabidiol alone or in combination with morphine using the formalin test in male and female mice
DE Sepulveda, DP Morris… - Cannabis and …, 2022 - liebertpub.com
Introduction: Phytocannabinoids have emerged as a potential alternative treatment option
for individuals experiencing persistent pain. However, evidence-based research regarding …
for individuals experiencing persistent pain. However, evidence-based research regarding …
[HTML][HTML] Cannabidiol is a potential therapeutic for the affective-motivational dimension of incision pain in rats
Background: Pain involves different brain regions and is critically determined by emotional
processing. Among other areas, the rostral anterior cingulate cortex (rACC) is implicated in …
processing. Among other areas, the rostral anterior cingulate cortex (rACC) is implicated in …
Differential effects of cannabidiol and a novel cannabidiol analog on oxycodone place preference and analgesia in mice: An opioid abuse deterrent with analgesic …
HM Harris, W Gul, MA ElSohly… - Cannabis and …, 2022 - liebertpub.com
Background and Purpose: This study sought to determine whether cannabidiol (CBD) or a
CBD derivative, CBD monovalinate monohemisuccinate (CBD-val-HS), could attenuate the …
CBD derivative, CBD monovalinate monohemisuccinate (CBD-val-HS), could attenuate the …
Opioid and cannabinoid synergy in a mouse neuropathic pain model
NP Kazantzis, SL Casey, PW Seow… - British Journal of …, 2016 - Wiley Online Library
Background and Purpose Clinical studies have reported that pan‐cannabinoid receptor
agonists may have efficacy in neuropathic pain states and that this might be enhanced by co …
agonists may have efficacy in neuropathic pain states and that this might be enhanced by co …
[HTML][HTML] Analgesic effects and impairment in locomotor activity induced by cannabinoid/opioid combinations in rat models of chronic pain
Both opioids and cannabinoids have well-known antinociceptive effects in different animal
models of chronic pain. However, unwanted side effects limit their use. The aim of this study …
models of chronic pain. However, unwanted side effects limit their use. The aim of this study …
Cannabis constituent synergy in a mouse neuropathic pain model
SL Casey, N Atwal, CW Vaughan - Pain, 2017 - journals.lww.com
Cannabis and its psychoactive constituent D9-tetrahydrocannabinol (THC) have efficacy
against neuropathic pain, however, this is hampered by their side effects. It has been …
against neuropathic pain, however, this is hampered by their side effects. It has been …