Transactive response DNA‐binding protein‐43 (TDP‐43) is involved in gene regulation via
the control of RNA transcription, splicing, and transport. TDP‐43 is a major protein …

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by
progressive degeneration of motor neurons leading to skeletal muscle denervation. Earlier …

The ultimate deficit in ALS is neuromuscular junction (NMJ) loss, producing permanent
paralysis, ultimately in respiratory muscles. However, understanding the functional and …

Denervation of the neuromuscular junction (NMJ) precedes the loss of motor neurons (MNs)
in amyotrophic lateral sclerosis (ALS). ALS is characterized by a motor unit (MU)-dependent …

Several lines of evidence indicate that neuromuscular junction (NMJ) destruction and
disassembly is an early phenomenon in amyotrophic lateral sclerosis (ALS). Here we …

Amyotrophic lateral sclerosis (ALS) represents the major adult-onset motor neuron disease.
Analyses of ALS animal models have shown that motor neuron death starts with …

Amyotrophic lateral sclerosis is a devastating, progressive neurodegenerative disease that
affects upper and lower motor neurons. Although several genes are identified as the cause …

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease with an extremely
heterogeneous clinical and genetic phenotype. In our efforts to find therapies for ALS, the …

Cortical hyperexcitability and mislocalization of the RNA-binding protein TDP43 are highly
conserved features in amyotrophic lateral sclerosis (ALS). Nevertheless, the relationship …

Amyotrophic lateral sclerosis (ALS) is a late-onset neuromuscular disease characterized by
progressive loss of motor neurons (MNs) preceded by neuromuscular junction (NMJ) …