Background CCN1 (also called Cyr 61) is an extracellular matrix signaling molecule that has
been implicated in neovascularization through its interactions with several endothelial …

Retinal neovascularization (RNV) is a characteristic pathological finding of retinopathy of
prematurity (ROP). Cysteine-rich 61 [Cyr61, also known as CCN family member 1 (CCN1)] …

AIM To investigate the role of CCR7/p-ERK1/2/VEGF signaling in the mouse model of
oxygen-induced retinopathy (OIR). METHODS Neonatal C57BL/6J mice were evenly …

Retinal vascular damages are the cardinal hallmarks of retinopathy of prematurity (ROP), a
leading cause of vision impairment and blindness in childhood. Both angiogenesis and …

Background Retinal neovascularization (NV) is a major cause of blindness associated with
ischemic retinal disorders. Our study was focused on evaluating the inhibitory effect of …

Purpose: Retinal vascular disease represents a major cause for vision loss in the Western
world. Recent research has shown that neuronal and vascular damage are closely related in …

Purpose The incidence of retinopathy of prematurity (ROP) has increased continuously in
recent years. However, the therapeutic effects of current treatments still remain undesired …

Purpose: KC7F2 is a novel molecule compound that can inhibit the translation of hypoxia-
inducible factor 1α (HIF1α). It has been reported to exhibit potential antiangiogenic effect …

Purpose: To explore the inhibitory effect of insulin-like growth factor binding protein-related
protein 1 (IGFBP-rP1) on retinal angiogenesis and its underlying molecular mechanisms in …

AIM To investigate the effects of the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002
on retinal neovascularization (RNV) in the oxygen-induced retinopathy (OIR) mouse model …