Identification of abnormally methylated–differentially expressed genes and pathways in osteoarthritis: a comprehensive bioinformatic study

L Zheng, W Chen, G Xian, B Pan, Y Ye, M Gu… - Clinical …, 2021 - Springer
Objectives To investigate abnormally methylated–differentially expressed genes (DEGs) and
their related pathways in osteoarthritis (OA) by comprehensive bioinformatic analysis …

Combined bioinformatics analysis reveals gene expression and DNA methylation patterns in osteoarthritis

D Song, W Qi, M Lv, C Yuan… - Molecular Medicine …, 2018 - spandidos-publications.com
Osteoarthritis (OA) is a common type of arthritis, which may cause pain and disability.
Alterations in gene expression and DNA methylation have been proven to be associated …

Aberrantly hydroxymethylated differentially expressed genes and the associated protein pathways in osteoarthritis

Y Fang, P Wang, L Xia, S Bai, Y Shen, Q Li, Y Wang… - PeerJ, 2019 - peerj.com
Background The elderly population is at risk of osteoarthritis (OA), a common, multifactorial,
degenerative joint disease. Environmental, genetic, and epigenetic (such as DNA …

Candidate methylated genes in osteoarthritis explored by bioinformatics analysis

J Liu, Y Hao, Y Wang, S Hu, K Xu, C Lu - The Knee, 2016 - Elsevier
Background This study aimed to explore potential novel genes correlated with osteoarthritis
(OA). Methods The gene expression profile of GSE48422 was downloaded from the Gene …

Genome‐wide expression and methylation profiles reveal candidate genes and biological processes underlying synovial inflammatory tissue of patients with …

J Yang, N Wang - International journal of rheumatic diseases, 2015 - Wiley Online Library
Aim The aim of the study was to identify osteoarthritis (OA)‐related biological markers and
processes. Methods The gene expression profile GSE 46750 including 12 normal and 12 …

Analysis of methylation datasets identified significantly changed genes and functional pathways in osteoarthritis

B Han, Z Zheng, J Ren, W Qiu, X Li - Clinical Rheumatology, 2019 - Springer
Background Researches indicate that epigenetics was involved in osteoarthritis (OA). The
purpose of this study was to describe the alterations of DNA methylation in hip and knee OA …

Effect of DNA methylation on gene transcription is associated with the distribution of methylation sites across the genome in osteoarthritis

P Yi, X Xu, J Yao, B Qiu - … and Therapeutic Medicine, 2021 - spandidos-publications.com
Genetics and epigenetics are important subjects in the field of osteoarthritis (OA) research.
DNA methylation may affect gene transcription, but the specific mechanisms have remained …

Identification of differentially expressed and methylated genes associated with rheumatoid arthritis based on network

D Zhang, ZF Li, RQ Zhang, XL Yang, DD Zhang… - …, 2020 - Taylor & Francis
Rheumatoid arthritis (RA) is a multi-systemic inflammatory autoimmune disease involving
peripheral joints, and the pathogenesis is not clear. Studies showed that DNA methylation …

The identification of hub-methylated differentially expressed genes in osteoarthritis patients is based on epigenomic and transcriptomic data

ZC Chu, T Cong, JY Zhao, J Zhang, ZY Lou… - Frontiers in …, 2023 - frontiersin.org
Introduction Osteoarthritis (OA) refers to a commonly seen degenerative joint disorder and a
major global public health burden. According to the existing literature, osteoarthritis is …

Identification of pathogenic genes related to rheumatoid arthritis through integrated analysis of DNA methylation and gene expression profiling

L Zhang, S Ma, H Wang, H Su, K Su, L Li - Gene, 2017 - Elsevier
The purpose of our study was to identify new pathogenic genes used for exploring the
pathogenesis of rheumatoid arthritis (RA). To screen pathogenic genes of RA, an integrated …