Despite wide vaccination coverage with efficacious vaccines, pertussis is still not under
control in any country. Two types of vaccines are available for the primary vaccination series …

Publisher Summary This chapter describes Bordetella pertussis and discusses recent
advances in the development of pertussis vaccines. Bordetella pertussis is the pathogen that …

Universal pertussis vaccination has successfully decreased pertussis mortality and morbidity
in childhood. However, despite intensive vaccination of young children, pertussis remains a …

Pertussis is an epidemic disease caused by Bordetella pertussis and also to a lesser extent
by Bordetella parapertussis. Classical illness lasts 4–8 weeks and is characterized by …

Pertussis or whooping cough is a life-threatening childhood disease, particularly severe
during the first months of life, although adolescent and adult pertussis is increasingly more …

Universal pertussis vaccination continues to prevent a previously common and serious
disease of childhood. Despite widespread gains in disease control, pertussis has not been …

Current vaccines against pertussis have proved their safety and efficacy in large-scale
clinical trials. Despite high vaccination coverage, pertussis is still prevalent and increasing …

Vaccines against pertussis have been used for more than a hundred years. This review
describes the development of whole-cell (wP) and acellular pertussis (aP) vaccines, which …

Rates of infection with Bordetella pertussis, the gram-negative bacterium that causes the
respiratory disease called whooping cough or pertussis, have not abated and 16 million …

The mechanisms of infection and immunity in pertussis are not well understood, and as a
result, the development of a new, improved vaccine is difficult. This paper describes the …