We aimed to explore the possible influence of CYP2C9 (* 2,* 3 and IVS8-109 A> T),
CYP2C19 (* 2,* 3 and* 17) and ABCB1 (1236C> T, 2677G> A/T and 3435C> T) on …

Phenytoin (PHT) is an antiepileptic drug widely used in the treatment of focal epilepsy and
status epilepticus, and effective in controlling focal seizures with and without tonic–clonic …

Background Epilepsy is a serious health problem worldwide. Despite the introduction of new
antiepileptic drugs (AEDs) almost 30% of these patients have drug-resistant forms of the …

OBJECTIVE: CYP2C9 is a major enzyme in human drug metabolism and the polymorphism
observed in the corresponding gene may affect therapeutic outcome during treatment. The …

To search for the optimal dosage of phenytoin in patients with epilepsy based on the
metabolic activities of CYP2C9 and CYP2C19 polymorphisms, a total of 169 patients …

Phenytoin has a widespread use in epilepsy treatment and is mainly metabolized by hepatic
cytochrome P450 enzymes (CYP). We have investigated CYP2C9* 2, CYP2C9* 3 …

Abstract Objective Cytochrome P450 2C9 and 2C19 (CYP2C9 and CYP2C19, respectively)
genetic polymorphisms play an important role in phenytoin (PHT) metabolism. We have …

The objective of this study was to study the effect of CYP2C9 genetic polymorphism and
undernourishment on free phenytoin concentrations in epileptic patients. The study was …

Background: Genetic polymorphisms of CYP2C9 can lead to wide inter-individual variations
in drug metabolism. Decreased metabolism leads to higher plasma levels, causing adverse …

Background Identified the polymorphisms of CYP2D6, CYP2C9, CYP2C19 and CYP3A4,
within a rigorously selected population of pediatric patients with drug-resistant epilepsy …