[PDF][PDF] Varying intolerance of gene pathways to mutational classes explain genetic convergence across neuropsychiatric disorders

S Shohat, E Ben-David, S Shifman - Cell reports, 2017 - cell.com
Genetic susceptibility to intellectual disability (ID), autism spectrum disorder (ASD), and
schizophrenia (SCZ) often arises from mutations in the same genes, suggesting that they …

Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis

AD Grotzinger, TT Mallard, WA Akingbuwa, HF Ip… - Nature …, 2022 - nature.com
We interrogate the joint genetic architecture of 11 major psychiatric disorders at
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …

[HTML][HTML] Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations

E Rees, HDJ Creeth, HG Hwu, WJ Chen… - Nature …, 2021 - nature.com
People with schizophrenia are enriched for rare coding variants in genes associated with
neurodevelopmental disorders, particularly autism spectrum disorders and intellectual …

[HTML][HTML] Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice

JL Doherty, MJ Owen - Genome medicine, 2014 - Springer
Psychiatric disorders such as schizophrenia, bipolar disorder, major depressive disorder,
attention-deficit/hyperactivity disorder and autism spectrum disorder are common and result …

[PDF][PDF] Comparative analyses of copy-number variation in autism spectrum disorder and schizophrenia reveal etiological overlap and biological insights

I Kushima, B Aleksic, M Nakatochi, T Shimamura… - Cell reports, 2018 - cell.com
Compelling evidence in Caucasian populations suggests a role for copy-number variations
(CNVs) in autism spectrum disorder (ASD) and schizophrenia (SCZ). We analyzed 1,108 …

All for one and one for all: heterogeneity of genetic etiologies in neurodevelopmental psychiatric disorders

D Moreno-De-Luca, CL Martin - Current opinion in genetics & development, 2021 - Elsevier
Alexandre Dumas' famous phrase All for One and One for All recapitulates our current
understanding of the genomic architecture of neurodevelopmental psychiatric disorders …

[HTML][HTML] Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders

X Yao, JT Glessner, J Li, X Qi, X Hou, C Zhu… - Translational …, 2021 - nature.com
Neuropsychiatric disorders, such as autism spectrum disorder (ASD), attention deficit
hyperactivity disorder (ADHD), schizophrenia (SCZ), bipolar disorder (BIP), and major …

[PDF][PDF] De novo synonymous mutations in regulatory elements contribute to the genetic etiology of autism and schizophrenia

A Takata, I Ionita-Laza, JA Gogos, B Xu, M Karayiorgou - Neuron, 2016 - cell.com
We analyze de novo synonymous mutations identified in autism spectrum disorders (ASDs)
and schizophrenia (SCZ) with potential impact on regulatory elements using data from …

Exome sequencing in schizophrenia-affected parent–offspring trios reveals risk conferred by protein-coding de novo mutations

DP Howrigan, SA Rose, KE Samocha, M Fromer… - Nature …, 2020 - nature.com
Protein-coding de novo mutations (DNMs) are significant risk factors in many
neurodevelopmental disorders, whereas schizophrenia (SCZ) risk associated with DNMs …

Exploring the genetic overlap between twelve psychiatric disorders

C Romero, J Werme, PR Jansen, J Gelernter… - Nature …, 2022 - nature.com
The widespread comorbidity among psychiatric disorders demonstrated in epidemiological
studies,,,–is mirrored by non-zero, positive genetic correlations from large-scale genetic …