[PDF][PDF] Varying intolerance of gene pathways to mutational classes explain genetic convergence across neuropsychiatric disorders
Genetic susceptibility to intellectual disability (ID), autism spectrum disorder (ASD), and
schizophrenia (SCZ) often arises from mutations in the same genes, suggesting that they …
schizophrenia (SCZ) often arises from mutations in the same genes, suggesting that they …
Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis
We interrogate the joint genetic architecture of 11 major psychiatric disorders at
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …
[HTML][HTML] Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations
E Rees, HDJ Creeth, HG Hwu, WJ Chen… - Nature …, 2021 - nature.com
People with schizophrenia are enriched for rare coding variants in genes associated with
neurodevelopmental disorders, particularly autism spectrum disorders and intellectual …
neurodevelopmental disorders, particularly autism spectrum disorders and intellectual …
[HTML][HTML] Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice
JL Doherty, MJ Owen - Genome medicine, 2014 - Springer
Psychiatric disorders such as schizophrenia, bipolar disorder, major depressive disorder,
attention-deficit/hyperactivity disorder and autism spectrum disorder are common and result …
attention-deficit/hyperactivity disorder and autism spectrum disorder are common and result …
[PDF][PDF] Comparative analyses of copy-number variation in autism spectrum disorder and schizophrenia reveal etiological overlap and biological insights
I Kushima, B Aleksic, M Nakatochi, T Shimamura… - Cell reports, 2018 - cell.com
Compelling evidence in Caucasian populations suggests a role for copy-number variations
(CNVs) in autism spectrum disorder (ASD) and schizophrenia (SCZ). We analyzed 1,108 …
(CNVs) in autism spectrum disorder (ASD) and schizophrenia (SCZ). We analyzed 1,108 …
All for one and one for all: heterogeneity of genetic etiologies in neurodevelopmental psychiatric disorders
D Moreno-De-Luca, CL Martin - Current opinion in genetics & development, 2021 - Elsevier
Alexandre Dumas' famous phrase All for One and One for All recapitulates our current
understanding of the genomic architecture of neurodevelopmental psychiatric disorders …
understanding of the genomic architecture of neurodevelopmental psychiatric disorders …
[HTML][HTML] Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders
X Yao, JT Glessner, J Li, X Qi, X Hou, C Zhu… - Translational …, 2021 - nature.com
Neuropsychiatric disorders, such as autism spectrum disorder (ASD), attention deficit
hyperactivity disorder (ADHD), schizophrenia (SCZ), bipolar disorder (BIP), and major …
hyperactivity disorder (ADHD), schizophrenia (SCZ), bipolar disorder (BIP), and major …
[PDF][PDF] De novo synonymous mutations in regulatory elements contribute to the genetic etiology of autism and schizophrenia
We analyze de novo synonymous mutations identified in autism spectrum disorders (ASDs)
and schizophrenia (SCZ) with potential impact on regulatory elements using data from …
and schizophrenia (SCZ) with potential impact on regulatory elements using data from …
Exome sequencing in schizophrenia-affected parent–offspring trios reveals risk conferred by protein-coding de novo mutations
Protein-coding de novo mutations (DNMs) are significant risk factors in many
neurodevelopmental disorders, whereas schizophrenia (SCZ) risk associated with DNMs …
neurodevelopmental disorders, whereas schizophrenia (SCZ) risk associated with DNMs …
Exploring the genetic overlap between twelve psychiatric disorders
The widespread comorbidity among psychiatric disorders demonstrated in epidemiological
studies,,,–is mirrored by non-zero, positive genetic correlations from large-scale genetic …
studies,,,–is mirrored by non-zero, positive genetic correlations from large-scale genetic …