Introduction Aortic pulse wave velocity (Ao-PWV) predicts cardiovascular and kidney
disease in type 2 diabetes (T2D). Klotho is a circulating antiaging hormone (sKlotho) with …

Background Evidence suggests that the anti-aging protein a-Klotho is a central modulator of
mineral homeostasis. Circulating a-Klotho exerts endocrine activity and has been implicated …

Background & Objective. The prevalence of arterial stiffness increases with age while the
klotho level decreases with age. Klotho deficiency increases circulating aldosterone levels …

Background Low levels of the Klotho protein are associated with accelerated tissue aging,
including arterial stiffness, in patients with cardiovascular and renal diseases. However, this …

Background Klotho, a protein linked to aging, has emerged as a pivotal player in mineral
bone metabolism and might explain the relationship between chronic kidney disease (CKD) …

Background Klotho was originally identified in a mutant mouse strain unable to express the
gene that consequently showed shortened life spans. In humans, low serum Klotho levels …

Senescence-accelerated mice P1 (SAMP1) is an aging model characterized by shortened
lifespan and early signs of senescence. Klotho is an aging-suppressor gene. The purpose of …

The anti-aging function of Klotho gene has been implicated in age-related diseases. The
physiological importance of Klotho in the progression of arterial stiffness with aging …

Klotho, an important anti-aging protein, may be related to elevated blood pressure (BP) and
arterial stiffness. We aimed to investigate associations between the serum klotho …

Results Higher serum OPG levels were associated with older age, female gender, greater
systolic BP, lower estimated GFR, and lower serum albumin. OPG was not associated with …