Abstract The precuneus (PreC; Brodmann area 7), a key hub within the default mode
network (DMN) displays amyloid and tau‐containing neurofibrillary tangle (NFT) pathology …

Hippocampal CA1 pyramidal neurons, a major component of the medial temporal lobe
memory circuit, are selectively vulnerable during the progression of Alzheimer's disease …

The posterior cingulate cortex (PCC) is a key hub of the default mode network underlying
autobiographical memory retrieval, which falters early in the progression of Alzheimer's …

Alzheimer's disease (AD) is characterized by accumulation of β‐amyloid plaques (AP) and
neurofibrillary tangles (NFT) in the cortex, together with synaptic loss and amyloid …

Down syndrome (DS) is the most prevalent cause of intellectual disability (ID). Individuals
with DS show a variety of cognitive deficits, most notably in hippocampal learning and …

The hallmark amyloid-β and tau deposition of Alzheimer's disease (AD) represents only a
fraction of its diverse pathophysiology. Molecular subtyping using large-scale-omic …

Background Reduction of precuneus choline acetyltransferase activity co-occurs with
greater beta-amyloid (Aβ) in Alzheimer's disease (AD). Whether this cholinergic deficit is …

The pathogenesis of neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) is poorly
understood, but changes in the expression of specific messenger RNAs (mRNAs) may …

Down syndrome (DS) is caused by the triplication of human chromosome 21 (HSA21) and is
the most common genetic cause of intellectual disability, with individuals having deficits in …

The posterior cingulate cortex, a key hub of the default mode network, underlies
autobiographical memory retrieval and displays hypometabolic changes early in Alzheimer …