Age-related gene expression in the frontal cortex suggests synaptic function changes in specific inhibitory neuron subtypes
Genome-wide expression profiling of the human brain has revealed genes that are
differentially expressed across the lifespan. Characterizing these genes adds to our …
differentially expressed across the lifespan. Characterizing these genes adds to our …
Native-state proteomics of Parvalbumin interneurons identifies novel molecular signatures and metabolic vulnerabilities to early Alzheimer's disease pathology
One of the earliest pathophysiological perturbations in Alzheimer's Disease (AD) may arise
from dysfunction of fast-spiking parvalbumin (PV) interneurons (PV-INs). Defining early …
from dysfunction of fast-spiking parvalbumin (PV) interneurons (PV-INs). Defining early …
Cerebrospinal fluid proteome alterations associated with neuropsychiatric symptoms in cognitive decline and Alzheimer's disease
Although neuropsychiatric symptoms (NPS) are common and severely affect older people
with cognitive decline, little is known about their underlying molecular mechanisms and …
with cognitive decline, little is known about their underlying molecular mechanisms and …
Structural (dys) connectivity associates with cholinergic cell density of the nucleus basalis of Meynert in Alzheimer's disease
CP Lin, I Frigerio, BDC Boon, Z Zhou, AJM Rozemuller… - bioRxiv, 2021 - biorxiv.org
Cognitive deficits in Alzheimer's disease, specifically amnestic (memory dominant) deficits,
are associated with cholinergic degeneration in the basal forebrain. The cholinergic nucleus …
are associated with cholinergic degeneration in the basal forebrain. The cholinergic nucleus …
Distinct changes in functional connectivity in posteromedial cortex subregions during the progress of Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder which causes
dementia, especially in the elderly. The posteromedial cortex (PMC), which consists of …
dementia, especially in the elderly. The posteromedial cortex (PMC), which consists of …
Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia
Objective Previous gene expression analysis identified a network of coexpressed genes that
is associated with β‐amyloid neuropathology and cognitive decline in older adults. The …
is associated with β‐amyloid neuropathology and cognitive decline in older adults. The …
Posterior cingulate cortex network predicts Alzheimer's disease progression
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
accumulation of toxic misfolded proteins, which are believed to have propagated from …
accumulation of toxic misfolded proteins, which are believed to have propagated from …
The fusiform gyrus exhibits differential gene-gene co-expression in Alzheimer's disease
A Ribeiro-dos-Santos, LM de Brito… - Frontiers in Aging …, 2023 - frontiersin.org
Alzheimer's Disease (AD) is an irreversible neurodegenerative disease clinically
characterized by the presence of β-amyloid plaques and tau deposits in various regions of …
characterized by the presence of β-amyloid plaques and tau deposits in various regions of …
Single-nucleus chromatin accessibility profiling highlights distinct astrocyte signatures in progressive supranuclear palsy and corticobasal degeneration
Tauopathies such as progressive supranuclear palsy (PSP) and corticobasal degeneration
(CBD) exhibit characteristic neuronal and glial inclusions of hyperphosphorylated Tau …
(CBD) exhibit characteristic neuronal and glial inclusions of hyperphosphorylated Tau …
Neuroinflammation and brain functional disconnection in Alzheimer's disease
Neuroinflammation and brain functional disconnection result from β-amyloid (Aβ)
accumulation and play fundamental roles in the pathogenesis of Alzheimer's disease (AD) …
accumulation and play fundamental roles in the pathogenesis of Alzheimer's disease (AD) …