Background Allergic rhinitis is characterized by nasal inflammation in response to allergen
exposure. Nasal allergen challenges are used in clinical trials evaluating drug effects …

Background Allergic rhinitis is an inflammatory disease that causes cellular influx and
mediator release in the nose. These inflammatory changes might be used as nasal …

Background: The objective was to validate acoustic rhinometry (AR) in a nasal challenge
with allergen. Methods: Nasal response to allergen provocation was based on clinical and …

Background Similar immune responses in the nasal and bronchial mucosa implies that
nasal allergen challenge (NAC) is a suitable early phase experimental model for drug …

Background Acoustic rhinometry (AR) is commonly used as a quantitative assessment of
nasal response to nasal allergen challenge (NAC). However, sources of error and physical …

Background: Nasal lavage is a noninvasive method of obtaining inflammatory exudates
following nasal allergen challenge (NAC), and permits cells and released mediators to be …

Objective The objective of this study was to evaluate nasal mucosal swelling with acoustic
rhinometry in subjects with asthma and in healthy controls. Methods We examined 184 …

Background Nasal allergen challenge (NAC) models have been used to study allergic
rhinitis and new therapies. Symptoms and biological samples can be evaluated at time …

Background: We have found that acoustic rhinometry is a reliable means of assessing nasal
airway caliber changes during the immediate reaction to nasal allergen challenge of …

Objective The nasal provocation test is not widely available due to lack of standardized
methods and related research. We evaluated the clinical utility of the nasal provocation test …