Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease
Genetic association studies have identified 215 risk loci for inflammatory bowel disease,,,,,,,,
thereby uncovering fundamental aspects of its molecular biology. We performed a genome …
thereby uncovering fundamental aspects of its molecular biology. We performed a genome …
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Several risk factors for Crohn's disease have been identified in recent genome-wide
association studies. To advance gene discovery further, we combined data from three …
association studies. To advance gene discovery further, we combined data from three …
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …
Fine-mapping inflammatory bowel disease loci to single-variant resolution
Inflammatory bowel diseases are chronic gastrointestinal inflammatory disorders that affect
millions of people worldwide. Genome-wide association studies have identified 200 …
millions of people worldwide. Genome-wide association studies have identified 200 …
Many inflammatory bowel disease risk loci include regions that regulate gene expression in immune cells and the intestinal epithelium
M Mokry, S Middendorp, CL Wiegerinck, M Witte… - Gastroenterology, 2014 - Elsevier
Background & Aims The contribution of genetic factors to the pathogenesis of inflammatory
bowel disease (IBD) has been established by twin, targeted-sequencing, and genome-wide …
bowel disease (IBD) has been established by twin, targeted-sequencing, and genome-wide …
Common variants at five new loci associated with early-onset inflammatory bowel disease
The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common
causes of morbidity in children and young adults in the western world. Here we report the …
causes of morbidity in children and young adults in the western world. Here we report the …
[HTML][HTML] Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci
The chronic inflammatory bowel diseases (IBDs)—Crohn disease (CD) and ulcerative colitis
(UC)—are idiopathic, inflammatory disorders of the gastrointestinal tract. These conditions …
(UC)—are idiopathic, inflammatory disorders of the gastrointestinal tract. These conditions …
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease
MA Rivas, M Beaudoin, A Gardet, C Stevens… - Nature …, 2011 - nature.com
More than 1,000 susceptibility loci have been identified through genome-wide association
studies (GWAS) of common variants; however, the specific genes and full allelic spectrum of …
studies (GWAS) of common variants; however, the specific genes and full allelic spectrum of …
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
A Franke, T Balschun, TH Karlsen, J Sventoraityte… - Nature …, 2008 - nature.com
Inflammatory bowel disease (IBD) typically manifests as either ulcerative colitis (UC) or
Crohn's disease (CD). Systematic identification of susceptibility genes for IBD has thus far …
Crohn's disease (CD). Systematic identification of susceptibility genes for IBD has thus far …
Recent insights into the genetics of inflammatory bowel disease
JH Cho, SR Brant - Gastroenterology, 2011 - Elsevier
Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders that comprise
Crohn's disease (CD) and ulcerative colitis (UC). Genome-wide association studies have …
Crohn's disease (CD) and ulcerative colitis (UC). Genome-wide association studies have …