Two novel heparin-binding vascular endothelial growth factor splices, L-VEGF144 and L-VEGF138, are expressed in human glioblastoma cells

CC Shen, WY Cheng, MT Chiao… - Current …, 2016 - ingentaconnect.com
The expression levels of different vascular endothelial growth factor A (VEGF) isoforms are
associated with the angiogenesis and the patient's prognoses in human cancers …

Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF121 and VEGF165 but not VEGF189

SY Cheng, M Nagane, HJS Huang… - Proceedings of the …, 1997 - National Acad Sciences
The vascular endothelial growth factor (VEGF) has been shown to be a significant mediator
of angiogenesis during a variety of normal and pathological processes, including tumor …

Vascular endothelial growth factor isoforms display distinct activities in promoting tumor angiogenesis at different anatomic sites

P Guo, L Xu, S Pan, RA Brekken, ST Yang… - Cancer research, 2001 - AACR
The gene for the major angiogenic factor, vascular endothelial growth factor (VEGF),
encodes several spliced isoforms. We reported previously that overexpression of two VEGF …

VEGF162, a new heparin-binding vascular endothelial growth factor splice form that is expressed in transformed human cells

T Lange, N Guttmann-Raviv, L Baruch… - Journal of Biological …, 2003 - ASBMB
The splice forms of vascular endothelial growth factor (VEGF) differ in biological properties
such as the receptor types that they recognize and their interaction with heparan sulfate …

The α-helical domain near the amino terminus is essential for dimerization of vascular endothelial growth factor

G Siemeister, D Marmé, G Martiny-Baron - Journal of Biological Chemistry, 1998 - ASBMB
Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen and a key
mediator of aberrant endothelial cell proliferation and vascular permeability in a variety of …

Production of Soluble Human Vascular Endothelial Growth Factor VEGF-A165-Heparin Binding Domain in Escherichia coli

A Seyedarabi, L Cheng, I Zachary, S Djordjevic - PloS one, 2013 - journals.plos.org
We report a method for production of soluble heparin binding domain (HBD) of human
vascular endothelial growth factor VEGF-A165. Recombinant VEGF-A165-HBD that contains …

High expression of a novel splicing variant of VEGF, L-VEGF144 in glioblastoma multiforme is associated with a poorer prognosis in bevacizumab treatment

WY Cheng, CC Shen, MT Chiao, YJ Liang… - Journal of Neuro …, 2018 - Springer
Introduction A previous study confirmed that a novel splicing variant of large vascular
endothelial growth factor (L-VEGF) termed L-VEGF144, a nucleolus protein, is found in …

Identification and characterization of a new splicing variant of vascular endothelial growth factor: VEGF183

J Lei, A Jiang, D Pei - Biochimica et Biophysica Acta (BBA)-Gene Structure …, 1998 - Elsevier
We report the discovery of a new splicing variant of vascular endothelial growth factor
named VEGF183. It is six amino acids shorter than its closest relative, VEGF189, due to the …

Expression of vascular endothelial growth factor in human brain tumors

R Nishikawa, SY Cheng, R Nagashima… - Acta …, 1998 - Springer
Compared to normal brain an increased expression of vascular endothelial growth factor
(VEGF) has been reported in many types of brain tumors. However, the numbers of samples …

A novel method to purify recombinant vascular endothelial growth factor (VEGF121) expressed in yeast

D Mohanraj, T Olson, S Ramakrishnan - Biochemical and biophysical …, 1995 - Elsevier
VEGF is a potent mitogen for vascular endothelial cells in vitro and acts as an angiogenic
factor in vivo. VEGF121 differs from the other isoforms in that it lacks the heparin-binding …