Endocytic pathways provide the primary route for therapeutic and diagnostic nanoparticles
(NPs) to enter cells and subcellular compartments. A better understanding of these cell entry …

Endocytosis mechanisms are one of the methods that cells use to interact with their
environments. Endocytosis mechanisms vary from the clathrin-mediated endocytosis to the …

Covalent coupling with cell-penetrating peptides (CPPs) has been a common strategy to
facilitate the cell entry of nanomaterial and other macromolecules. Though efficient, this …

Macropinocytosis is a widely-observed and evolutionarily-conserved endocytic process
found in the eukaryotic cells. In comparison to other endocytic routes, macropinocytosis …

The cellular uptake of nanoparticles (NPs) represents a critical step in nanomedicine and a
crucial point for understanding the interaction of nanomaterials with biological systems. No …

• Introduction• Membrane ruffling and the formation of the macropinosome• Rabs and
macropinocytosis• The fate of the macropinosome on the endocytic pathway• A role for …

Nanoparticles (NP) are attractive options for the therapeutic delivery of active
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …

Nanoparticles (NPs) are of similar size to typical cellular components and proteins, and can
efficiently intrude living cells. A detailed understanding of the involved processes at the …

Macropinocytosis is a form of endocytosis that allows massive uptake of extracellular
materials and is a promising route for intracellular delivery of biofunctional macromolecules …

Cell-penetrating peptides (CPPs) have been widely used to deliver nanomaterials and other
types of macromolecules into mammalian cells for therapeutic and diagnostic use. Cationic …