Flavonoids share a common structural framework that serves as a hallmark indicative of their
biological activity. In this study, we investigated the effects of two structurally similar …

Fisetin (3, 7, 3′, 4′-tetrahydroxyflavone), a flavonol compound of flavonoids, exhibits a
broad spectrum of biological activities including anti-oxidant, anti-inflammatory, anti-cancer …

Abstract Heat shock factor 1 (HSF1) is a transcription factor for heat shock proteins (HSPs)
expression that enhances the survival of cancer cells exposed to various stresses. HSF1 …

Unlike normal tissues, cancers experience profound alterations in protein homeostasis.
Powerful innate adaptive mechanisms, especially the transcriptional response regulated by …

Environmental stress induces damage that activates an adaptive response in any organism.
The cellular stress response is based on the induction of cytoprotective proteins, the so …

A bioflavonoid quercetin suppressed the stress response in heat-shocked cells and we have
investigated the inhibitory mechanism in this report. After treatment of cells with nonlethal …

Quercetin is a flavonoid well known to inhibit growth and heat shock protein (HSP) synthesis
of cancer cells. However, sunphenon has been scarcely reported concerning effects on …

Heat shock proteins (HSPs) are induced by various physical, chemical, and biological
stresses. HSPs are known to function as molecular chaperones, and they not only regulate …

Quercetin is a known specific inhibitor of hsp70 synthesis and thus might be a potent agent
for enhancing the selective cytotoxicity of heat on tumour cells. A comparative analysis of the …

Coniferyl aldehyde (1) is previously reported as a potent inducer of heat shock factor 1
(HSF1). Here, we further examined the active pharmacophore of 1 for activation of HSF1 …