Guiding neuron development with planar surface gradients of substrate cues deposited using microfluidic devices
Wiring the nervous system relies on the interplay of intrinsic and extrinsic signaling
molecules that control neurite extension, neuronal polarity, process maturation and …
molecules that control neurite extension, neuronal polarity, process maturation and …
Development-on-chip: in vitro neural tube patterning with a microfluidic device
CJ Demers, P Soundararajan… - …, 2016 - journals.biologists.com
Embryogenesis is a highly regulated process in which the precise spatial and temporal
release of soluble cues directs differentiation of multipotent stem cells into discrete …
release of soluble cues directs differentiation of multipotent stem cells into discrete …
New perspectives on neuronal development via microfluidic environments
LJ Millet, MU Gillette - Trends in neurosciences, 2012 - cell.com
Understanding the signals that guide neuronal development and direct formation of axons,
dendrites, and synapses during wiring of the brain is a fundamental challenge in …
dendrites, and synapses during wiring of the brain is a fundamental challenge in …
Combined chemical and topographical guidance cues for directing cytoarchitectural polarization in primary neurons
AC Greene, CM Washburn, GD Bachand, CD James - Biomaterials, 2011 - Elsevier
Chemical and topographical cues can be used to guide dissociated neurons into user-
defined network geometries on artificial substrates, yet control of neuron polarity …
defined network geometries on artificial substrates, yet control of neuron polarity …
Axon guidance of rat cortical neurons by microcontact printed gradients
R Fricke, PD Zentis, LT Rajappa, B Hofmann, M Banzet… - Biomaterials, 2011 - Elsevier
Substrate-bound gradients expressed in numerous spatio-temporal patterns play a crucial
role during the development of complex neural circuits. A deeper understanding of the axon …
role during the development of complex neural circuits. A deeper understanding of the axon …
Combined microfluidics/protein patterning platform for pharmacological interrogation of axon pathfinding
Assembly of functional neural circuits relies on the ability of axons to navigate a complex
landscape of guidance cues in the extracellular environment. In this report, we investigate …
landscape of guidance cues in the extracellular environment. In this report, we investigate …
Local presentation of L1 and N‐cadherin in multicomponent, microscale patterns differentially direct neuron function in vitro
The ability to pattern multiple bioactive cues on a surface is valuable for understanding how
neurons interact with their complex extracellular environment. In this report, we introduce a …
neurons interact with their complex extracellular environment. In this report, we introduce a …
Local Polymer Replacement for Neuron Patterning and in Situ Neurite Guidance
H Dermutz, RR Grüter, AM Truong, L Demkó… - Langmuir, 2014 - ACS Publications
By locally dispensing poly-l-lysine (PLL) molecules with a FluidFM onto a protein and cell
resistant poly-l-lysine-graft-polyethylene glycol (PLL-g-PEG) coated substrate, the …
resistant poly-l-lysine-graft-polyethylene glycol (PLL-g-PEG) coated substrate, the …
Nanotopographic control of neuronal polarity
We employ simple geometrical rules to design a set of nanotopographies able to interfere
with focal adhesion establishment during neuronal differentiation. Exploiting nanoimprint …
with focal adhesion establishment during neuronal differentiation. Exploiting nanoimprint …
Textural guidance cues for controlling process outgrowth of mammalian neurons
JN Hanson, MJ Motala, ML Heien, M Gillette… - Lab on a Chip, 2009 - pubs.rsc.org
We explore textural cues as a mechanism for controlling neuronal process outgrowth in
primary cultures of mammalian neurons. The work uses a form of decal transfer lithography …
primary cultures of mammalian neurons. The work uses a form of decal transfer lithography …
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