Eumelanin is photoprotective for pigmented tissues while pheomelanin is phototoxic. In this
review, we summarize current understanding of how eumelanin and pheomelanin structures …

Eumelanin is photoprotective while pheomelanin is phototoxic to pigmented tissues.
Ultraviolet A (UVA)‐induced tanning seems to result from the photooxidation of pre‐existing …

Eumelanin photoprotects pigmented tissues from ultraviolet (UV) damage. However, UVA‐
induced tanning seems to result from the photooxidation of preexisting melanin and does …

It is generally considered that eumelanin (EM) is photoprotective while pheomelanin (PM) is
phototoxic. A recent study using a mouse model demonstrated that PM produces reactive …

Pheomelanogenesis is a complex pathway that starts with the oxidation of tyrosine (or
DOPA, 3, 4‐dihydroxyphenylalanine) by tyrosinase in the presence of cysteine, which …

Although photodegradation of the retinal pigment epithelium (RPE) melanin may contribute
to the etiology of age‐related macular degeneration, the molecular mechanisms of this …

Normal melanocytes produce specialized subcellular organelles called melanosomes within
which the biochemical processes of melanogenesis occurs. During sunlight‐induced …

Melanins protect tissue by absorption and rapid nonradiative, nonreactive dissipation of
ultraviolet (UV) light. However, melanins also produce reactive oxygen species (ROS) upon …

Most of the research into melanins has focused on eumelanin [4]. However, there is
increasing knowledge of the physical and chemical properties of pheomelanin and …

Melanins are thought to be important modulators of photochemistry in skin. Eumelanin, a
black-brown pigment, is believed to protect against UV-induced photodamage, whereas …