Multiple studies have observed heterogeneous neuronal firing patterns as a local network
transitions to spontaneous seizures. We demonstrated that separately examining …

The role of inhibitory neuronal activity in the transition to seizure is unclear. On the one
hand, seizures are associated with excessive neuronal activity that can spread across the …

Mechanisms of seizure initiation are unclear. To evaluate the possible roles of inhibitory
neurons, unit recordings were obtained in the dentate gyrus, CA3, CA1, and subiculum of …

Abstract See Lenck-Santini (doi: 10.1093/awx205) for a scientific commentary on this article.
Epileptic seizures represent altered neuronal network dynamics, but the temporal evolution …

The onset of focal seizures in humans and in different animal models of focal epilepsy
correlates with reduction of neuronal firing and enhanced interneuronal network activity …

Despite decades of research, our understanding of epilepsy, including how seizures are
generated and propagate, is incomplete. However, there is growing recognition that …

Patients with temporal lobe epilepsy (TLE), the most common form of epilepsy in adults,
often display cognitive deficits. The time course and underlying mechanisms of cognitive …

1 Chronically epileptic rats, produced by prior injection of pilocarpine, were used to
investigate whether changes in intrinsic neuronal excitability may contribute to the …

Temporal lobe seizures in humans correlate with stereotyped electrophysiological patterns
that can be reproduced in animal models to study the cellular and network changes …

Although much is known about persistent molecular, cellular, and circuit changes associated
with temporal lobe epilepsy, mechanisms of seizure onset remain unclear. The dentate …