Dear Sir, Simvastatin is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl
coenzyme A (HMG-CoA) re-ductase, which has become commercially available in Europe …

Simvastatin is an inhibitor of 3-hydroxy3-methylglutaryl coenzyme A (HMG-CoA) reductase
that is used as a cholesterol-lowering agent and is metabolized by cytochrome P-450^ sub …

ABSTRACT Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) or
statins are important drugs used in the treatment of dyslipidemia by reducing the …

aBsTRaCT The placebo-corrected incidence of rhabdomyolysis in a systematic review of 20
statin trials was 1.6/100,000 per year. It is likely to be higher than this in everyday clinical …

Rhabdomyolysis is a rare but potentially fatal complication associated with the use of
cholesterol synthesis inhibitors (statins). The complication can develop in susceptible …

The objectives of this article were to review the mechanism and clinical significance of
statins-macrolides interaction, determine which combination has the highest risk for the …

Statins as lipid lowering drugs, are safe and effective in reducing cardiovascular disease
risk, but rarely produce myopathy like myalgia, myositis or rhabdomyolysis. We report the …

Case description A 75-year-old man developed rhabdomyolysis and acute renal failure
during atorvastatin therapy. All medications were discontinued and the patient was treated …

SUMMARY A 66 year-old woman with no history of renal or liver disease presented with
progressive asthenia and diffuse myalgia. She cited 5 months history of mild hyperlipidemia …

Objective: To report an unusual case of simvastatin-induced rhabdomyolysis and to discuss
the occurrence of this potentially fatal adverse effect. Case Summary: A 61-year-old white …