A large percentage of the US population is either receiving or should be considered for
statin therapy. Whether through primary or secondary prevention for atherosclerotic disease …

Objective Simvastatin has been shown to play an important role in reducing the risk of
cardiovascular events caused by atherosclerosis. To promote the understanding of the …

Objective: To review the literature regarding statins and myotoxicity and evaluate these data
to determine whether incidence rates are higher with simvastatin. Data Sources: Literature …

The mechanisms of statin-induced muscle injury are not fully understood, and early
recognition of statin myopathy is critical in order to prevent serious sequelae. The case of a …

Statins are an established class of drugs with proven efficacy in cardiovascular risk
reduction. The concern over statin safety was first raised with the revelation of myopathy and …

Introduction Rhabdomyolysis is a rare, but serious and potentially fatal adverse reaction of
the statin application that may be developed in any time of therapy. It is characterized by …

A 67-year old man was hospitalized due to an aorto-coronary bypass and cecal perforation.
After administration of atorvastatin, amiodarone, and fluconazole, rhabdomyolysis …

Purpose Statins rarely cause serious muscle toxicity and rhabdomyolysis. The aim of our
investigation was to identify and quantify potential risk factors for statin‐induced …

Neuromyopathy is a rare side effect of chronic colchicine therapy, especially without renal
impairment. Drugs interacting with colchicine metabolism through CYP3A4 can accelerate …

We report the case of a 79‐year‐old man with mild chronic renal failure who developed
severe rhabdomyolysis after combined exposure to simvastatin and colchicine. Colchicine …