Analyzing neuronal activity during human seizures is pivotal to understanding mechanisms
of seizure onset and propagation. These analyses, however, invariably using extracellular …

Epileptic cortex is characterized by paroxysmal electrical discharges. Analysis of these
interictal discharges typically manifests as spike–wave complexes on …

Purpose: Focal seizures are thought to reflect simultaneous activation of a large population
of neurons within a discrete region of pathologic brain. Resective surgery targeting this focus …

Temporal lobe seizures in humans correlate with stereotyped electrophysiological patterns
that can be reproduced in animal models to study the cellular and network changes …

In vitro brain tissue preparations allow the convenient and affordable study of brain networks
and have allowed us to garner molecular, cellular, and electrophysiologic insights into brain …

The relationship between clinically accessible epileptic biomarkers and neuronal activity
underlying the transition to seizure is complex, potentially leading to imprecise delineation of …

High frequency oscillations have been proposed as a clinically useful biomarker of seizure
generating sites. We used a unique set of human microelectrode array recordings (four …

Abstract Objective Interictal discharges (IIDs) and high frequency oscillations (HFOs) are
established neurophysiologic biomarkers of epilepsy, while microseizures are less well …

Objective To better understand the mechanisms that lead to the sudden and unexpected
occurrence of seizures, with the neuronal correlate being abnormally synchronous …

Abstract Treatment of patients with drug-resistant focal epilepsy relies upon accurate seizure
localization. Ictal activity captured by intracranial EEG has traditionally been interpreted to …