As other tubular organs, the embryonic heart develops from an epithelial sheet of cells,
referred to as the heart field. The second heart field, which lies in the dorsal pericardial wall …

Publisher Summary This chapter discusses the findings that preceded and led to the
identification of this progenitor cell population, and different molecular and genetic …

Heart tube elongation occurs by progressive addition of cells from pharyngeal mesoderm to
the poles of the heart. These progenitor cells, termed the second heart field, contribute to …

The vertebrate heart tube forms from epithelial progenitor cells in the early embryo and
subsequently elongates by progressive addition of second heart field (SHF) progenitor cells …

Extension of the vertebrate heart tube is driven by progressive addition of second heart field
(SHF) progenitor cells to the poles of the heart. Defects in this process cause a spectrum of …

During vertebrate heart development, two progenitor populations, first and second heart
fields (FHF, SHF), sequentially contribute to longitudinal subdivisions of the heart tube (HT) …

At the end of the first week of mouse gestation, cardiomyocyte differentiation initiates in the
cardiac crescent to give rise to the linear heart tube. The heart tube subsequently elongates …

Many vertebrate organs are derived from monolayered epithelia that undergo
morphogenesis to acquire their shape. Whereas asymmetric left/right gene expression …

Early heart morphogenesis involves a process in which embryonic precursor cells are
instructed to form a cyclic contracting muscle tube connected to blood vessels, pumping …

In this review, we focus on two important steps in the formation of the embryonic heart:(i) the
progressive addition of late differentiating progenitor cells from the second heart field that …