Cochlear synaptopathy (or hidden hearing loss), due to noise exposure or aging, has been
demonstrated in animal models using histological techniques. However, diagnosis of the …

Evidence from animal and human studies suggests that moderate acoustic exposure,
causing only transient threshold elevation, can nonetheless cause “hidden hearing loss” that …

Hidden hearing loss: current concepts : Current Opinion in Otolaryngology & Head and
Neck Surgery Hidden hearing loss: current concepts : Current Opinion in Otolaryngology & …

Standard audiometric evaluations are not sensitive enough to identify hidden hearing loss
(HHL) and/or cochlear synaptopathy (CS). Patients with either of these conditions frequently …

Investigations of cochlear synaptopathy in living humans rely on proxy measures of auditory
nerve function. Numerous procedures have been developed, typically based on the auditory …

Studies in multiple species, including in post-mortem human tissue, have shown that normal
aging and/or acoustic overexposure can lead to a significant loss of afferent synapses …

Objectives: Recent studies in animals indicate that even moderate levels of exposure to
noise can damage synaptic ribbons between the inner hair cells and auditory nerve fibers …

For decades, we have presumed the death of hair cells and spiral ganglion neurons are the
main cause of hearing loss and difficulties understanding speech in noise, but new findings …

Noise-induced cochlear synaptopathy has been demonstrated in numerous rodent studies.
In these animal models, the disorder is characterized by a reduction in amplitude of wave I of …

Auditory de-afferentation, a permanent reduction in the number of inner-hair-cells and
auditory-nerve synapses due to cochlear damage or synaptopathy, can reliably be …