Gene therapy is a promising strategy for treatments of various diseases. Efficient and safe
introduction of therapeutic genes into targeted cells is essential to realize functions of the …

25 kDa branched polyethylenimine (PEI) has successfully been used for in vitro and in vivo
gene delivery approaches, but it is cytotoxic. Smaller PEIs are usually non-cytotoxic but less …

Polyethylenimine (PEI) has been known as an efficient gene carrier with the highest cationic
charge potential. High transfection efficiency of PEI, along with its cytotoxicity, strongly …

Polyethyleneimine (PEI) is well-known as a non-viral gene delivery vector, especially for
oligonucleotide delivery. However, its clinical applications are significantly limited due to its …

A 25-kDa linear polyethylenimine (25kDa L-PEI) has proven to be efficient and versatile
agent for gene delivery. Therefore, we determined the optimal transfection conditions of …

Polyethylenimine (PEI) has been studied as an efficient and versatile in vitro and in vivo
gene delivery agent. Here, we report the in vivo fate, tissue expression duration, and safety …

The therapeutic application of commercially available polyethylenimines (eg, PEI 25 kD) is
marred by substantial toxicity. The benefit of using lower molecular weight …

Background Efficient gene transfer is a major challenge for non‐viral gene therapy.
Understanding how non‐viral vectors initiate gene expression could lead to the …

Low-molecular-weight polyethylenimine (LMW-PEI) was synthesized by the acid-catalyzed,
ring-opening polymerization of aziridine and compared with commercially available high …

There are several strategies that can be utilized to improve transfection efficiency while
reducing the cytotoxicity of polyethyleneimine (PEI) as a promising non-viral gene delivery …