Background Altered cell metabolism is regarded as a hallmark of cancer with numerous
studies highlighting glucose and glutamine as critical nutrients for tumor proliferation …

In this article, we briefly summarized evidence that cellular phosphate burden from
phosphate toxicity is a pathophysiological determinant of cancer cell growth. Tumor cells …

Tumor epidemiology, as well as tumor microenvironments and cancer cell signaling study,
has been presented with statistical relevance of inorganic phosphate (Pi) to tumorigenesis …

Simple Summary In spontaneous tumor regression, tumors shrink and disappear without
conventional treatments. This phenomenon challenges the view that cancer is an …

Phosphorus, often in the form of inorganic phosphate (Pi), is critical to cellular function on
many levels; it is required as an integral component of kinase signaling, in the formation and …

Noninvasive in vivo assessment of chemical tumor microenvironment (TME) parameters
such as oxygen (p O2), extracellular acidosis (pHe), and concentration of interstitial …

Inorganic phosphate (Pi) is required by all living organisms for the development of organs
such as bone, muscle, brain, and lungs, regulating the expression of several critical genes …

Tumor cells develop a high demand for inorganic phosphate (Pi) due to their high growth
rates and energy requirements. Serum Pi concentrations in cancer patients have been found …

The present perspective article proposes that cachexia, muscle wasting in cancer, is
mediated by dysregulated phosphate metabolism and phosphate toxicity that can damage …

Inorganic phosphate (Pi) is a vital component of nucleotides, membrane phospholipids, and
phosphorylated intermediates in cellular signalling. The Growth Rate Hypothesis (GRH) …