Diagnostic value of highly-sensitive chimerism analysis after allogeneic stem cell transplantation

L Sellmann, K Rabe, I Bünting, E Dammann… - Bone marrow …, 2018 - nature.com
Conventional analysis of host chimerism (HC) frequently fails to detect relapse before its
clinical manifestation in patients with hematological malignancies after allogeneic stem cell …

[HTML][HTML] Personalized chimerism test that uses selection of short tandem repeat or quantitative PCR depending on patient's chimerism status

J Tyler, L Kumer, C Fisher, H Casey, H Shike - The Journal of Molecular …, 2019 - Elsevier
Chimerism testing is used to monitor engraftment and risk of relapse after allogeneic
hematopoietic stem cell transplantation for hematologic malignancies. Although short …

[HTML][HTML] Clinical utility of quantitative PCR for chimerism and engraftment monitoring after allogeneic stem cell transplantation for hematologic malignancies

M Ahci, K Stempelmann, U Buttkereit, P Crivello… - Biology of Blood and …, 2017 - Elsevier
Although quantitative PCR (qPCR) has been explored for chimerism monitoring after
allogeneic stem cell transplantation (SCT), evidence regarding its clinical utility compared …

Chimerism monitoring techniques after hematopoietic stem cell transplantation: an overview of the last 15 years of innovations

P Tozzo, A Delicati, R Zambello, L Caenazzo - Diagnostics, 2021 - mdpi.com
Chimerism analysis is a well-established method for monitoring the state of hematopoietic
stem cell transplantation (HSCT) over time by analyzing peripheral blood or bone marrow …

Use of chimerism analysis after allogeneic stem cell transplantation: Belgian guidelines and review of the current literature

A Delie, A Verlinden, K Beel, D Deeren… - Acta Clinica …, 2021 - Taylor & Francis
Background: Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative
treatment option in both adult and pediatric patients with malignant and non-malignant …

Significance of chimerism in hematopoietic stem cell transplantation: new variations on an old theme

F Khan, A Agarwal, S Agrawal - Bone marrow transplantation, 2004 - nature.com
The main goal of post-transplantation monitoring in hematopoietic stem cell transplantation
(HSCT) is to predict negative events, such as disease relapse, graft rejection and graft …

Earlier relapse detection after allogeneic haematopoietic stem cell transplantation by chimerism assays: digital PCR versus quantitative real-time PCR of insertion …

J Valero-Garcia, MDC González-Espinosa, M Barrios… - PLoS …, 2019 - journals.plos.org
Background The analysis of molecular haematopoietic chimerisms (HC) has become a well-
established method to monitor the transplant evolution and to assess the risk of relapse after …

Ultrasensitive chimerism enhances measurable residual disease testing after allogeneic hematopoietic cell transplantation

SB Kanaan, F Urselli, JP Radich, JL Nelson - Blood Advances, 2023 - ashpublications.org
Increasing mixed chimerism (reemerging recipient cells) after allogeneic hematopoietic cell
transplant (allo-HCT) can indicate relapse, the leading factor determining mortality in blood …

Chimerism analysis for clinicians: a review of the literature and worldwide practices

AG Blouin, M Askar - Bone marrow transplantation, 2022 - nature.com
This review highlights literature pertinent to chimerism analysis in the context of
hematopoietic cell transplantation (HCT). We also conducted a survey of testing practices of …

Strategies and clinical implications of chimerism diagnostics after allogeneic hematopoietic stem cell transplantation

C Thiede, M Bornhäuser, G Ehninger - Acta haematologica, 2004 - karger.com
Abstract Analysis of donor chimerism has become a routine method for the documentation of
engraftment after allogeneic hematopoietic stem cell transplantation (HSCT). In recent years …